ID A0A3B1IVM2_ASTMX Unreviewed; 684 AA.
AC A0A3B1IVM2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSAMXP00000033605.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033605.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033605.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR AlphaFoldDB; A0A3B1IVM2; -.
DR Ensembl; ENSAMXT00000050818.1; ENSAMXP00000033605.1; ENSAMXG00000033143.1.
DR GeneTree; ENSGT01030000234598; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000033143; Expressed in intestine and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 163..249
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 351..559
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 563..679
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 684 AA; 75480 MW; E4F03A78AD228987 CRC64;
MLKKILLFGF AGLAVLAVGI LIGHFGIEQD NSPKWVRDLS QNVDESLIKK FIAEVDNMKI
QENLRKLTEV PHMATTPGDE ATVEYMLKRW QDKDSGLDAA WREDYRVYLS FPKKDTPNTV
TVVSPSNAVL FKAQEKEKAY TPDQEDPEVV QPYAAYGPAG HARGKLVYAN QGKVSDYELL
NRTLDLSGTI AIVRYGGAGR GAKAINAAPF GVVGVLVYTD PYDINDGLMS DENETYPHSW
YLPPSGAERG SFTSDFGDPL TPYLAAKKDT YRIPEENING APPIPIQPIG FGDAQALICE
LGGSAAPTDW QGSFPCTYNF GGPGFRDAST YRDSEVKLDV YNAGELRNST NVMGVIWGSV
EPDRYVMYGN HRDSWVHGAI DPSSGTAVML EITRILGEKV KSGKWRPRRT IIFGSWGAEE
FGLIGSAEYA EEYISKLSQR AVAYINVDIS VFANATLRAS ASPIAQNVIF TASKQVNAAG
SSSVSVYDNW LKYFNRTSPT YGLIPNVGYL TGAGSDYAPF IHYMGITSMD LSYTYDRSKT
RARIYPAYHT AYDTFDYASK YIDPEPLKEA VKSFRNAAAN LDRVIHSSDL LNETPLKARR
INDQLMLLDR AFVDPQAFPN KYAYRHVIWA SRTSGVATFP GLADAVEKAR TTGLKEDWAE
AHKHLSIVTQ AISGAAHTLT EVHQ
//
