ID A0A3B1IW34_ASTMX Unreviewed; 647 AA.
AC A0A3B1IW34;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000034143.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000034143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1IW34; -.
DR Ensembl; ENSAMXT00000044678.1; ENSAMXP00000034143.1; ENSAMXG00000042944.1.
DR GeneTree; ENSGT01100000263547; -.
DR InParanoid; A0A3B1IW34; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000042944; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..647
FT /note="NACHT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017353630"
FT DOMAIN 101..235
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 647 AA; 74221 MW; F8A2B29C0A5FCDFC CRC64;
MLICAVLFAI FICLLELSPP CHRKLKSTLK KKFHKINEGI SDPGTSILLN EIYTDLYITE
GGSGEVNNEH EVRQIEAASR RSVTQETPIK CNDLFKDQSI RTVLTKGVAG IGKTVSVQKF
ILDWTEGKAN QDVFFVFPLP FRELNLIKTK KLSLVDLLYQ FFKDTKDLKP KDYHCYKVMF
IFDGLDECRL TLDFQNNKRV SDVTQSASVD VLLTNLIQGN LLPSALLWIT TRPAAANQIP
PDCIDQVTEV RGFNDPQKEE YFRKRIRDQS LAKRIITHIR SSRSLYIMCH IPVFCWISAT
VLERMLGEAE GGEIPKTLTQ MFTHFLIFQL KHRSQKYQRE SDVDLDQTRE IILALGKLAF
QQLEKGNLIF YEEDLRECSI DVREVSVYSG VCTQIFRQES GLHLGKVFSF VHLSVQEFLE
TMSDFLKRAV DKALQSENGH LDLFLRFLLG LSLESNQTLL RGLLIQTENM SHSTEEVVEY
IKQKIRENPS PEKSISLFHC LNELNDHSLV QEVQKYLNRG GSSDLSGVKL SPDQWSAVAF
VMLNSEEELD EFNLRKCERA LYLDYFQKKV HSHRLEHLVF LIDYHFSLRL GWCNLSEKSC
ADLASALSSN YSTLRELNLS YNKLQDSGVK LLSAGLKSSH CKLEKLE
//
