ID A0A3B1IWG1_ASTMX Unreviewed; 1032 AA.
AC A0A3B1IWG1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 5 {ECO:0000313|Ensembl:ENSAMXP00000033885.1};
GN Name=KCNQ5 {ECO:0000313|Ensembl:ENSAMXP00000033885.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033885.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3B1IWG1; -.
DR STRING; 7994.ENSAMXP00000033885; -.
DR Ensembl; ENSAMXT00000050355.1; ENSAMXP00000033885.1; ENSAMXG00000004427.2.
DR GeneTree; ENSGT00940000155933; -.
DR InParanoid; A0A3B1IWG1; -.
DR OrthoDB; 2911641at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004427; Expressed in muscle tissue and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 2.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..329
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 439..577
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT DOMAIN 629..702
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 377..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 113938 MW; FAB66683BF7EB2C1 CRC64;
MPRGHGADDG ASGLWMKASP GRGAENLRLK DVEAARGAMN RTGRPGDGAD ELRSRAQGAR
LSLLGKPLAY SAQSGRRNAR YRKLQNYLYN VLERPRAWAF VYHAFVFILV FGCLVLSVFS
TIPAYMDLSN HCLLILEFVM IVVFGLEYII RIWSAGCCCR YRGWQGRLRF ARKPFCVIDI
IVLIASIAVV SAGSQGNIFA TSALRSLRFL QILRMVRMDR RGGTWKLLGS VVYAHSKELV
TAWYIGFLVL IFSSFLVYLV EKEFNKQFAT YADALWWGTI TLTTIGYGDK TPQTWPGRLL
SAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR NPAASLIQCV WRSYAADENS
VSIATWKPHL KALHTCSPTK KDQGESTTSK GHSNRQKLFR RYTTRRHSQK LSFKERVRMA
SPRGQSIKSR QTSLNDRRSP GTEVAGEGSS PAKVQKSWSF NDRTRFRPSL RLKSQSRAVP
EADSLGGDDY FDEKGCHCDV SMEDLSAPLK TVIRAVRIMK FHVAKKKFKE TLRPYDVKDV
IEQYSAGHLD MLCRIKSLQT RLDTIVGPPQ TLSSKSKTFS SPSLHLYYSQ AKRKHSAPGF
TTGMGPQQTL NPKARNLSSS SLHLYYSQSR KKHSSSGVDQ ILGKGQIPMD RKMRDRILPE
GESLEHDMSM LGRVCKVERQ VQSIESKLDS LLDVYRQVLQ KGSSSVLGLS ALPLFELEQT
SDYHSSIQSK DLSSSTQLSG SGVSRSASAN LPCGLQLVLA PSELNLGTGY PTSASSFSPS
PLLHNQPSSP DSVYPTSPPP ILTPNNLSRG HPNFSELSRP LPTTNPNTNT LQLPTMAPGT
PSSLISETLE ESRAESPNTC LLSTQTEAVS DREAKCSQSS VQLRSRPERS PKEEGSWRRH
LSLEINPLGL LSSPTNHPLH SDRGLGKSFS AQNLMLPSGG DCHPNLSARS SGSSNNESND
RETLPDWGNT ELFISDKELA TNKGNFNFLS QQSMDTSFTS ELVQTGTAGP SHSPAGPSGS
SDSLSLPHVH LK
//
