ID A0A3B1IWN7_ASTMX Unreviewed; 346 AA.
AC A0A3B1IWN7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Nuclear envelope integral membrane protein 1 {ECO:0000313|Ensembl:ENSAMXP00000034492.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000034492.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000034492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR AlphaFoldDB; A0A3B1IWN7; -.
DR STRING; 7994.ENSAMXP00000034492; -.
DR Ensembl; ENSAMXT00000036203.1; ENSAMXP00000034492.1; ENSAMXG00000005407.2.
DR GeneTree; ENSGT00390000002174; -.
DR InParanoid; A0A3B1IWN7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005407; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF4; NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 1; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 160..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 346 AA; 39428 MW; C9238FCCCE24753C CRC64;
MTSRIMAGKL KSKGESSLLR IRIRFTLAFL LFLLQLFQLS SGVPRSTIDV KDEQEVKIHE
AQHFCYINPV PDPGWKETWM RIQVQVRSSK ELKVTVASDE EKLDDLEHFS ISDLVQYFIR
EQTNETTVSV SLFSPKTCFR VDPSDSRTLY TVKPSRQFDI LLFLVFLAGL LLFFFADTLS
RSQLFYYSTG LSTGLTASLI ILIFVLGRFL PKKSSFYVLI VGGWSFALYL IQLVFKNLQV
ILKEYWHLAA AYVAVVGFIS FAVCYRHGPL VEERSINILS WTLQLFGMLL IYAGIQVQQV
ALAIMVAAFC SKNLEYPVTM AITLFSLLLL HHVSINYVKI PRTVSA
//
