ID   A0A3B1IWS4_ASTMX        Unreviewed;       751 AA.
AC   A0A3B1IWS4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=N-acetyl-alpha-glucosaminidase {ECO:0000313|Ensembl:ENSAMXP00000034532.1};
GN   Name=NAGLU {ECO:0000313|Ensembl:ENSAMXP00000034532.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000034532.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000034532.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007236414.1; XM_007236352.2.
DR   AlphaFoldDB; A0A3B1IWS4; -.
DR   STRING; 7994.ENSAMXP00000034532; -.
DR   Ensembl; ENSAMXT00000030037.1; ENSAMXP00000034532.1; ENSAMXG00000043894.1.
DR   GeneID; 103022100; -.
DR   KEGG; amex:103022100; -.
DR   CTD; 4669; -.
DR   GeneTree; ENSGT00390000005900; -.
DR   InParanoid; A0A3B1IWS4; -.
DR   OrthoDB; 1112009at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000043894; Expressed in intestine and 9 other cell types or tissues.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024240; NAGLU_N.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
DR   Pfam; PF12971; NAGLU_N; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..751
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017457841"
FT   DOMAIN          42..124
FT                   /note="Alpha-N-acetylglucosaminidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12971"
FT   DOMAIN          139..474
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          482..739
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
SQ   SEQUENCE   751 AA;  85800 MW;  C2D483E3F519725C CRC64;
     MTAARVSALL PLLVVLAVVA ASADGALENI RATADDETQS RAVAELLRRL LGDRAREFVV
     SVNRSLSAGG LDVCELRSTR NNRVVAVGSS GVAAATGIYN YLKYFCNCHV SWSGDQLDLP
     RPLPPLTGVL RIQSPHRFRY YQNVCTSSYS MVWWDWPRWQ REIDWMALNG INLPLAFLGQ
     EALWQEVYMS LGLNQTELNQ FFTGPAFLAW NRMGNLFAWG GPLPQSWHLK QLSLQLKILD
     RMRAFGMIPV LPAFAGIVPH GITRLFPQAN VTKLAPWSRF NCSYSCAYVL DPRDPLFRRI
     GSMFLTLVVR LFGTDHVYNT DTFNEQTPAS SDPTYLSSIS HAIFTTMTSV DPQAVWLMQA
     WLFINEPDFW KPPQVKALLH GVPLGRMIVL DLFADSVPAY SFTQSFYGQP FIWCMLHNFG
     GNRNLFGTVE SVNLGPFEAL RFPNSTLVGL GMAPEGIEQN PVVYELMSEM AWRKEPVNLV
     KWASLYASRR YGNMNESLTA AWRLLFRSVY NCTIPGYKNH NRDPLVRRPS LKLKTDVWYD
     PADLYEAWKL LFEAAPSLVS VETFRYDLVD VTRQALQLLA FEFYKEIRDS FQAQKLPELL
     VAGGVLVYDL IPELDRLLSS DQHFLLGVWL EQARSFGLDE QEAQLYDINA RNQITLWGPD
     GEILDYANKD WAGLMEDYYL QRWGLFVNTL VECLDRGRPF KQDTFNQAVF QVENGFVYNQ
     RKYPSKPRGD TYEIARLIFL KYYPHALKRL K
//