ID A0A3B1IZR3_ASTMX Unreviewed; 799 AA.
AC A0A3B1IZR3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neural EGFL like 2b {ECO:0000313|Ensembl:ENSAMXP00000035151.1};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSAMXP00000035151.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000035151.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000035151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B1IZR3; -.
DR STRING; 7994.ENSAMXP00000035151; -.
DR Ensembl; ENSAMXT00000038596.1; ENSAMXP00000035151.1; ENSAMXG00000016579.2.
DR GeneTree; ENSGT00810000125439; -.
DR InParanoid; A0A3B1IZR3; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000016579; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 245..304
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 415..456
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 457..497
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 498..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 530..576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 577..612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 613..668
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 673..732
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 500..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 518..527
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 799 AA; 89166 MW; C9B36F4153DF4263 CRC64;
MRTLSRGRAD GPAASFSMRL FQLSALISVS LLSSDMWRSV RASAGVSERM MQKLRGRVEF
TLLLTLKQDK FNSGVMLSIH HGEQRYLELE SSGQRSEVRL HYWTAERQIH TEVFPYSLAD
GRWHRVALSL SATQLVLYVD CSRIYERVVG TPSMEVPAGS TVWLGQRNNA HGFYKGVMQD
VQLLLMPQGY ISQCPDLNRT CPTCNDFHGL VQKIMELQDI LAKTSGKLAR AEERMRALDG
CYCERTCSMN GELYRDEEVW IDGCRNCTCS NGTVECESIF CPVPQCPPDT AAAYIPAACC
KECQPVCLFR GRVYVEGDRR SVRDSTGNCL LFECRDRSMR RAESTPCPEL TCPESEQITL
TDRCCKVCRG HDFCAEGYSS SCVENSECVN LEAGACCNCR DGYQALRDDS AYCQDVDECA
EGKHYCRENT VCVNTPGSFM CVCQTGYIRI DDYSCTEHDE CGSGLHSCDE NALCFNTVGG
HSCTCKPGYM GNGTVCRAHC DGLCHNGGTC VAPDTCICQQ GFTGRRCETD IDECSDGFVE
CDSRATCVNL PGWYHCECRD GYHDNGMFSA NGESCEDIDE CETGRHSCAN DTLCFNMDGG
YDCRCPHGKN CSGDCVHDGK VKHNRQIWVL DDDRCSVCSC QSGLVMCRRM VCDCENPTVD
VSCCPECDPR LTSQCLQQNG LLTYNNGDTW VENCQQCQCM RGEVDCWPVP CTPVLNCEFL
VVPEGECCPR CISDPCQADT VRNDITKTCV DEYGVTRFSG SAWTKHSTEC SLCQCKVTYI
HTQTQRHTIH LYTLFLDFN
//
