ID A0A3B1J063_ASTMX Unreviewed; 533 AA.
AC A0A3B1J063;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM domain-containing protein 6-like {ECO:0000313|Ensembl:ENSAMXP00000035548.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000035548.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000035548.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1J063; -.
DR Ensembl; ENSAMXT00000056885.1; ENSAMXP00000035548.1; ENSAMXG00000036110.1.
DR GeneTree; ENSGT00940000162787; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036110; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF7; FERM DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..533
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017207019"
FT DOMAIN 1..308
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 329..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 61701 MW; BA28AD2B26C49F9B CRC64;
MLRRMVRVLF VFSLIEPIVK QISRVNSCCF CLLCERSLTS CLCVLVRPAD NEHMFVDLED
RLAKYFPKEW KQDSGKGNQK RWIPPLLCLK VQYYVENGRL ICERKARRLY YADLRERVLR
SECRQQEEVY FQLAGYALQA DLGDHPPENS QQDAPYFRPK DYFPPWIVAK RGVDYLLCHG
PKVHRELWGM PCRDAVLLFI RESCRLEDVP VTFYRLHKDK REEKGSALLG LTLRGMQVYQ
EMNNVRELLY DFPWTNVGRL TFLGKKFEIQ PDGLPSARKL VYYTGSAFRS RHLLLHLSSS
HRLYLTLQPA LTHLRQLEQD EEKKRYRESY ISDDMDPDPL SSDGSPLLSR HSTSSSGIEA
DGRQRSVSVE MVSVEEEDKT RPEEEEWHDE DFQQHVNGPG EVSVDDPEET LRLAELLQGV
SVDCPSLSSE INSAGEKNLL MGKKLTIILL FFTLQVLKWK TRGSSERHSH SLDDVRLMPR
PLLLSTLPNT SRSYTFGLGT GADPQKPTFY GRRSTNCLAL DLLEDEQFLE LVL
//
