ID A0A3B1J085_ASTMX Unreviewed; 449 AA.
AC A0A3B1J085;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR036924};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000035331.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000035331.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in several stages of intracellular trafficking.
CC {ECO:0000256|PIRNR:PIRNR036924}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR036924}.
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DR AlphaFoldDB; A0A3B1J085; -.
DR STRING; 7994.ENSAMXP00000035331; -.
DR Ensembl; ENSAMXT00000041080.1; ENSAMXP00000035331.1; ENSAMXG00000003482.2.
DR GeneTree; ENSGT00940000154632; -.
DR InParanoid; A0A3B1J085; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003482; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014637; SNX5/SNX6/SNX32.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR45850; SORTING NEXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45850:SF5; SORTING NEXIN-5; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF036924; Snx5_Snx6; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036924};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036924}.
FT DOMAIN 70..217
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 26..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 51752 MW; 60554957B229A5A5 CRC64;
MFSSALLLLP PRSSFLQQRK IKGKVAAKIK TERRESPRSL THRPTRSSAA MTSISQDADR
EKMRSVSVDL NNDSSLLIDI PDALCERDKV KFTVHTKTTL NSFQKPEFSV PRQHEDFIWL
HDTLVETEEY AGLIIPPAPP KPDFEGPREK MHKLGEGEST MTKEEYAKMK QELEAEYLAV
FKKTVQVHEI FLQRLSSHPV FSKDRNFQIF LEYDQDLSVR RKNAKEFFGG FFKNMVKSAD
EVLISGIKDV DEFFEQEKTF LLDYFSKIKD ATAKAEKMTR SHKNVADDYI HISATVSNIG
AEDNTALKTH LEKFSELLEK LRKVEGRVAS DQELKLTELL RYYMRDIQAA KDLLYRRARA
LADYENSNKA LDKARLKSKD IPQAEENQRQ CLQKFDKLSE SGKQELTSFK GRRVVAFRKN
LIEMAELEIK HAKNSTALLQ GCIEMLKVN
//
