ID A0A3B1J1Y9_ASTMX Unreviewed; 768 AA.
AC A0A3B1J1Y9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Vitrin {ECO:0000313|Ensembl:ENSAMXP00000035384.1};
GN Name=VIT {ECO:0000313|Ensembl:ENSAMXP00000035384.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000035384.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000035384.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1J1Y9; -.
DR Ensembl; ENSAMXT00000050338.1; ENSAMXP00000035384.1; ENSAMXG00000009121.2.
DR GeneTree; ENSGT00940000159330; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009121; Expressed in pharyngeal gill and 7 other cell types or tissues.
DR CDD; cd01472; vWA_collagen; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF23; VITRIN; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..768
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017276835"
FT DOMAIN 33..126
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 343..528
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 545..678
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 150..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 83692 MW; EA3A599FB3050983 CRC64;
MFRASTISVC VVLLLICRGD AKPNGKSKKA KQVVPDIECD IRAGKISYPE FIVRCPAGCR
ETMQRVYGTG IYASISSICN AAIHSGVITN TGGKVIVKKM AGQAEYKGSH AYGVRSLSLP
NWRESFTVEV GKPNKGVIYP TTLEYTASKP TTVKTGQKEA KASPVSTVLP TTTTPEPTTT
TTPEPTTTTT TTTTTTTTTT PPPTTTTTTP PTTTTTTTKQ RAAVHKVRDA GSSHPYYASV
AAAANARQSQ TSQGKGLPQA FRGGPAIAGR FSPRINPGVR RPDAGTPIRR QPSSPSTSAF
NRVKVLQPER NENSNPRFST REQDSLPRAP EIMSQGDPNC KVDIAFLMDG SWSIGKRRFK
IQKDFLAEVS QVINVGVAGP MMGIIQYGDD PVTEFSLRQY SNSKELKPAI DKIMQKGGLS
NVGKALSYIN KHYFSDANGN RGGAPNVAVV LVDGWPTDKV EEASRQARES GINIFFVTIE
GPDDNEKHNV VEPNFVDKAV CRTNGFFSLP VASWFALRKA VQPLVKRVCD TDRLVCSKTC
LNANDIAFVI DGSSSVGTGN FRTVLQFVAN VTREFEISDT DTRVGAVQYT YEQRLEFAFG
QHNTKADLLN AIKRINYWSG GTSTGAAITY AAEQLFSKSK PNKRKIMIVI TDGRSYDDVR
APALAVHRSG VIAYSIGIAW GGSGRAGVHR HRPRPRPLLL RGRVRQPLQI RAEDHPQHLP
GVQLSAAELS HAQSLWRHLQ DVQAHHSIIA FSLLSLYGLL ESWVELRF
//
