ID A0A3B1J5M4_ASTMX Unreviewed; 841 AA.
AC A0A3B1J5M4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Si:ch211-42i9.8 {ECO:0000313|Ensembl:ENSAMXP00000037582.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000037582.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000037582.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
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DR AlphaFoldDB; A0A3B1J5M4; -.
DR STRING; 7994.ENSAMXP00000037582; -.
DR Ensembl; ENSAMXT00000057097.1; ENSAMXP00000037582.1; ENSAMXG00000039317.1.
DR GeneTree; ENSGT00390000009391; -.
DR InParanoid; A0A3B1J5M4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000039317; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 1.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 1.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 6..832
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 37..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 92969 MW; 1788C567B9CC0368 CRC64;
WASAEFDLAQ IRLIVHQDCE RRGRQVLFDS KAIRKLDPSE PNAEETKVPP ARSGACQINS
KASQKESPPT YQYTRPASDV NMLGEMMFGS VAMSYKGSTL KIHHISPPQL MVSKVFSTRH
GSSNLQDSFE SISQTCPSHT SSIHSNPVDM PGRGHSEDGD SGIARSSLSS LLATPMPSPG
SSSSSGCASS YQRRWLRSQA TSLQHGPIPR STEEMFSLSD ESCSSNPAMA RRRKKIAVSI
IISLPEKEEE SHSFQEFFFS HFPLFESHMN KLKTAIERAM IVCRRVAEAS QRVQVYLCRV
MEALGEFMTV WNLYMAPRIT EPVWLTMVSQ SAERNQLCQR FLKEMSVLME HGAKTFLSAL
LTAVLMYHLA WVPTVMPSNH LPIKPVCQKP TSHTVDLLAK SHPYNPLWAQ LDLYGALGSP
VRVCRTVVVG RRRELVQRVL YILSYFIRCS DLQENAQPQG HTDSPANPCP AQYSNSAPLS
ERTNETPLIP KSEAAKPPVC TENTNDKTLS ANVDGANDAP VSERTSKKAP KSDSAGPSPL
PEPTSERLAC ADPGWEPFGD ATDPVGGGLE HILANQSPPV QRVKFTIGSP RESDHDGQRC
GRGLHRKLPH RRLADMRRNE SSDSSLGDSD EEETASPSQQ AYTPATETAR EYELPLPCQT
ESRASVNHFG RSLLGGYCPQ YMPDFALHGI SSDQRLKQCL MTDLEHTVLL QHPALDEPVA
EAVCIVADTD RLCVQVATSQ RRVCEPGRLG RDVMVSSLVH TLLTSVLQLH TLNIAADFCV
MHLEDRLQEI YFKSCSLAEY LRGQRRVHVK ELGLALIESS DLPLLAAVAS THSPYVAQIL
L
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