ID A0A3B1J5R5_ASTMX Unreviewed; 999 AA.
AC A0A3B1J5R5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NLR family CARD domain-containing protein 3-like {ECO:0000313|Ensembl:ENSAMXP00000036679.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000036679.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000036679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1J5R5; -.
DR Ensembl; ENSAMXT00000054222.1; ENSAMXP00000036679.1; ENSAMXG00000041439.1.
DR GeneTree; ENSGT01100000263476; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000041439; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 160..294
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 783..999
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 940..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 113557 MW; 28698D8E20D577C6 CRC64;
MFVFNQELQQ KFISLVKNEL NTFKKLLSPD YPACSEREEE DDQREGVLMI TLHILRNMKQ
TDIANTLQSK LAPACQRKLK SKLRDKYQKI NEGISGYGNS ALLNEIYTEL YITEGGGGDV
NQEHEVKQIE AASRKRQTQE RPIKCNDIFK SLPEQNRPIR TVLTKGVAGI GKTVSVQKFI
LDWAEGEVNQ DVLFIFPLPF RELNLMKEKK LSLVNLLQSF FTETQDLKPR HYKGYKLMFI
FDGLDECRLS LDFQNNKKLV DIEEQTSVDV LLTNLIKGNL LPSALLWITS RPAAVSQIPP
ECVDQVTEVR GFSDPQKQEY FSKRIRNQDL ANKVFTHIRS SRSLYIMCHI PVFCWITASV
LERMLSEAES GEIPKTLTKM FTHFLIFQIK HKNQKYSGKS DPDPQQTREI ILALGKLAFQ
QLEKGNLIFY EEDLRESGID IREISVYSGV CTQIFMEEHE LHLGKVFSFV HLSIQEFLAA
LYAFLNRKIP KEQSTEQQTS KFFKLFSRST MTGFLSSAVD RALQSESGHL DLFLRFLLGL
SLDSNQTLLR VLLTPSERIS HSSKETVKYI KKKIEESSSP EKSINLFHCL NELNDHSLVQ
EVQKYLSGGA DRRLHQANLS PAQWSALAFV LVNSEEELDE FDISKYHPSE ECLMKLLPVV
KISRRALLAS CNLGVNTCEN LGSIINLENS SLKEVDLSNN DLQDSGVELL SSGLKSSHCK
LQILRLSGCM ITEKGCSSLA SALILNPSHL KELYLTYNHP GESGVKLLSA RLEDPHCKLE
TLRVEHGGKI RIKPGLKKWF CDFTLDPNTV NPRLSLSEEN RRVESVEERQ SYPDHPERFN
RCQQVLSREG VTGRCYWEAE WSGRGAVALS YKTISRKGRE SECWFGQNIN SWSLSCSDNS
FSVHHNDNRT VLPPPPSGCR RVGVYVDCPA GTLSFYSISR SPTPSPAHTH TLSPEHTHSQ
TPSDTLTHLH TFYTTFTQPL YAGIGVYYDG SSVHLCEIE
//
