ID A0A3B1J7A0_ASTMX Unreviewed; 1925 AA.
AC A0A3B1J7A0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Uncharacterized LOC103024598 {ECO:0000313|Ensembl:ENSAMXP00000038108.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038108.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000038108.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the actin family.
CC {ECO:0000256|RuleBase:RU000487}.
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DR Ensembl; ENSAMXT00000042122.1; ENSAMXP00000038108.1; ENSAMXG00000040643.1.
DR GeneTree; ENSGT00940000166728; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000040643; Expressed in embryo and 13 other cell types or tissues.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF390; ACTIN-LIKE ISOFORM X1; 1.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 31..153
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|Pfam:PF13716"
FT REGION 522..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1434..1467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..993
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1925 AA; 214604 MW; E48DB70D542B6624 CRC64;
MSGSSAGTFD QHGCPLVMFP TESQDKLVSD LTKEEVADFI SYFLRLHSKN KEECLVSVVA
DLREANLSIA RRVAESLLLL ELHRRTVHSV YVVQPRKRDA LKLLQKLLLP KKASYSPQNA
YKCVFLKEVC ELWNYIDRSQ LTASLGGYLV YCHSSWVSFV KEIDSFVQQF VAVVQRLPVC
ISALQSISAL PVPADPSRLS QFCSSNQAEL QQIRSDLGLD ELLRRCECVL EKFRFPESDQ
CYQAMVGTHL YTHTALEMLH NYERITAAVE KVELLWQQAF SKARGQLQLL NLQKEAQQVE
SQMDLVWQKL QSFSTETAAD GGSAETLKLE FEASVYTHAM ALVRRAEDVI HTLVENVGER
SVGEQWVVEL EQQKERFRSA VELQYSNIRT HCLFHQLHNK IQSWYSLAVC ESFLQDLLWV
TCCTEQDSQG DVSAGREWRP ALESFLRVHT CPQVEELVQL AHLANVISDP QLQNAGKQLA
HRCMNLRKLL TSPGSATLRD LQLALQWQYE YLKGSRETVN SDLIPRRNES TETVDSERSV
QRDSGFVSIM ASVRPSSSHP DLNKQDCVKN NPLRSAVLPD AASLAGKPPS LSSFDSGFEG
AGGGQIEGKE GQDGLPRMPY SRETTSRLKV PQLQISEENV SSMSDSEDLD HGTAGSNSTT
ASIHIIPRIT SDSLNFEIKV QRSATLPKNP WLSLPVDNLE SSYTVTISPS SPALQRPPKC
HSPSEHCRDQ PTQTDSQGCG YSTKQQDHEG SFREGEFSPI RNVLSSTMAE GGDQADGTTD
VPHTLLWDTY DLHDVRQDTS DRLSDISLGN WELEEQKELQ AVEEILGRTA GILQEEENVL
AQEVALDVLL KADHVGRQWP SWNHMSSSEL AEAGVIGLED DPTSPLRFNC RDSVSSSRPN
SEAISPAEQL LQPDRSRVLQ ELEDLQVLEE RIMEENMKIQ ELRLSEKTPE SRRKFLEELE
REKKEVEEME RSLRRETKKK REGKPKKRSQ RGPKVVKCSI MEMTMALQSF EDEDAVCDEA
LLMNCRRETQ ESKSLQSNSR HLDTATDGFI SCLDSGQSCT AMSVGLATEE FGHSIDVDQF
HEDYTKSVPS NSALDEIVHF PDKDQPHEPP DLITEDSTSS RPSNSGLREI INCESSNQPC
ASANFSTTEE STNSSPSNLI IDKLIDCVDS DQLCEPQDLT TEDSSLSRPS DSPLDELINC
AVSEQHRKTP DLTTEESTSF GPSDLSPSKI MECADSNQNH EQPLQLTTED SSLSRPLNPV
LEEIIQDLNQ IVLDSHCKDA ELGTDPPLIA ITKKPTNNDL YLSVDQDEDK QSIHSSPSKT
DGDVFTPGNS LITHTGSQMK ETGQQMDTSK SGMNENPSEI MKESWKTDES ESQSGDLKLM
EACQERAAFD PGGPKPHPRL QRMKKPLMHS GESSVSELNL ETCDHHDEFV VTGSTLLPSA
GPKPKERKNL PPRIYPSAAE HNRNNNNPRC ADLYRLDAET FLQEPAVEYV EYEAVDHTDV
DIVSQISETE SHGVCNKSAA KVTNTRIDEE PSTRTVCTSP ALHQQLQICS REASEFLTPV
VLDTGSGLVK AGFADQDLPS LIFPTAIGVP KYEEVMSSSV QQAVYVGHDA QHMRGVLTLH
YPMKNGIIDN WDQIEMIWQH VFRQLGVDPE DHPVLLTEGV LNPQGNRQRM VQTMFETFNV
PLTFIALQPV LALYAAGRTT GVVFDSGDGV SHSVPVFDGY SLPHAVQRLT LAGSDVTMQL
KKLLLEQGVC MRTSAELEIV RDIKERCCCV ALDFEVQLSK GGGASTPTHY TLPDGQIVSL
TTERFRAPEI LFKPELIGRD HYGIHESIFR SVLQSDIDLR KSFLGNIVLS GGNTLLAGLP
ERLQVELGNL APATECVKVI SAPDRDFSVW KGGAVLSSLP TFSSAWISRD EYEEFGPNIV
NRRCF
//
