ID A0A3B1J7G0_ASTMX Unreviewed; 650 AA.
AC A0A3B1J7G0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=BED-type domain-containing protein {ECO:0000259|PROSITE:PS50808};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000037259.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000037259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B1J7G0; -.
DR Ensembl; ENSAMXT00000030725.1; ENSAMXP00000037259.1; ENSAMXG00000030453.1.
DR GeneTree; ENSGT00940000158431; -.
DR InParanoid; A0A3B1J7G0; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000030453; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 1.10.10.1070; Zinc finger, BED domain-containing; 1.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR46481:SF2; ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR46481; ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF02892; zf-BED; 1.
DR SMART; SM00614; ZnF_BED; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF140996; Hermes dimerisation domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50808; ZF_BED; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00027}.
FT DOMAIN 40..98
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT REGION 516..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 72461 MW; EA81DDA9E05EB43B CRC64;
MRSFNVSRRS RETILFFRAA RSGWGDQLSM AEAGVQAPKN LKADVWLHFG FRSYGGREEL
DKSKAVCKLC NKELKYCGNT TNLRNHLTRH HPDTQKTAEP TQTPLEKAFA MKLPSSSPRA
KKISEALVTF ICKDIRPYSV VENVGFRSLI NVLEPRYVLP TRKHLSEVAI PNLYRDVKHG
VATSLKSTER VALTCDSWVS RAMDSYLTIT AHYIDNEWRL MSHVLQTREI ETSHTASNLA
ELLSEAIQEW ELANKDPAIV TDNAANMTRA VELTNLLHVG CFAHTLNLAS QAALKTPPVA
RLLGRVRRIA SFFHRSTTAS HQLKEKQKIL GLPAHKLVID VTTRWNSALE MLQRFLEQQP
AISAALLSPE VRRNESDLCT LSELDITVAE DVVKALGPLK AATLVMSEEK SPTLSVIAPL
HAQLLAEMNN VTHDSTVIKD LKTAAHTNLK SRYVVLKDKL YVASALDPRF KALPFLTDEA
RDNTFSKLVT EAAGLEPVEA SIQQSDDDGA EHIVPVEQED NSLDPVEVSD APTPPKKPKE
SSALMSLLGP SYTPKDTVSE KTPAVKATEE VNRYREVKPI PLSENPLTWW RLHAGEYPLL
ARQAKRYLCI PGTSVPSERV FSTAGDIVTA QRSCLTPQHV DQLLFLQKNL
//
