ID A0A3B1J891_ASTMX Unreviewed; 367 AA.
AC A0A3B1J891;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Torsin family 3 member A {ECO:0000313|Ensembl:ENSAMXP00000038512.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038512.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000038512.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235}.
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DR AlphaFoldDB; A0A3B1J891; -.
DR STRING; 7994.ENSAMXP00000038512; -.
DR Ensembl; ENSAMXT00000045424.1; ENSAMXP00000038512.1; ENSAMXG00000034163.1.
DR GeneTree; ENSGT00950000182888; -.
DR InParanoid; A0A3B1J891; -.
DR OrthoDB; 5087at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000034163; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR PANTHER; PTHR10760; TORSIN; 1.
DR PANTHER; PTHR10760:SF3; TORSIN-3A; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..367
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017454932"
FT DOMAIN 308..365
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
SQ SEQUENCE 367 AA; 41620 MW; 74F2ED754B72FC0B CRC64;
MIALLLLSAL LADPVSADFF QFNSLSNVST YYFNYIYCHV WEGDCQPNQE DASQQVPTGG
VWSWFSQDYT GMMTAWYCSL GQCCDSGDCR ITNNLTALER DLQMKLHGQH LAQSVVLKAV
QGFINNPESN KPLTLSFHGW SGTGKNYVAR MVADNLYRDG VKSECVRLFI APFHFPHTRL
VDMYKGQLRE AIRDMVLRCP QTLFIFDEAE KLHPGLIDAI KPYMDHYDNV DGVSYRRAIF
LFLSNIGGAA INEVALDFWH SGQNREDIGM EDLEHRLRSE SMDAEGGFAQ SELMSGHLID
FFVPFLPLEY RHVKLCARDA YAARGVEPDE ATLDEVAKAM LYVPKEEKLF SAQGCKSIPQ
RINFFLP
//
