UniProt: A0A3B1J8M1

Database: UniProt
Entry: A0A3B1J8M1_ASTMX

LinkDB:  A0A3B1J8M1_ASTMX 
Original site:  A0A3B1J8M1_ASTMX

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Ontology (5)   
   GO (5)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (34)   
   InterPro (16)   
   Pfam (8)   
   PROSITE (4)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (43)   

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ID   A0A3B1J8M1_ASTMX        Unreviewed;      1641 AA.
AC   A0A3B1J8M1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Complement C4-B-like {ECO:0000313|Ensembl:ENSAMXP00000038241.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038241.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000038241.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
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DR   Ensembl; ENSAMXT00000047103.1; ENSAMXP00000038241.1; ENSAMXG00000012282.2.
DR   GeneTree; ENSGT00940000155739; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000012282; Expressed in zone of skin and 13 other cell types or tissues.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00017; ANATO; 1.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.40.1930; -; 3.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR   InterPro; IPR041425; C3/4/5_MG1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF17790; MG1; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF01759; NTR; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00104; ANATO; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          661..697
FT                   /note="Anaphylatoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01178"
FT   DOMAIN          1492..1638
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
SQ   SEQUENCE   1641 AA;  184414 MW;  65C04DAC1E23E5D4 CRC64;
     YMILITAPNV VHLGVQETIS VQLHGATEAV DVTLYFRHLK KQPLSTRTTV NLNTNNQYQA
     VVTLTVHDYN RIKQKKDTRS NFVQLAAESK LFEAKPQLTN IYLSTRRGYI FIQTDKPIYN
     PGELVNFRIF TLDNYMKPID DLIYVKITVS INADSRARVT LLQHQQPEAG HWKITASYYN
     YGMSETSVEF EVREYVLPMF EVNIEATKPY LTLNSEFFPF SITARYTYGK GADGIAYVRF
     GLVDGKGERT YLPGIEKQIK VEDGRADCLL YTQDLLSAAA NQSLQNIEGM YLYIAATVLE
     KASGDLEEAE SSSVKIVNSP YVVDLSKTKK HFTPGGKFSI LGTTTFPDGS KVPTLKKATA
     TVTVNPGGPA EDVLIEENLE NNKGDIDFTF VVPEKAKTMF ITVSVEGGEE EVIISDANIT
     STATQPSKNC YLSVEVQHQV LQPGQNLQVT FRDITPPGTT RPSHIYYMVL SKGRVLMVGK
     VQRSDLTSTS LDFSEDMVPS FRLLAYYYTE GGSMGLVADS VWVDVKDVCK GKVEVDLKPA
     EEFEVLVRTD PDSSVALSAV DSAVYILNKR NKLSPQKMFD YMNSYDLACS VGGGEDSESV
     LQRVGLTYIS SFLESPILNQ HKCNKKEEKG HHQTKRDVDL SKLCNCFNFS VNSFKHADRK
     CCDDGRKLGL TLKSCDERLK KTRHQSESCR QAFKKCCEAA AARRKREKIN SMKLSLGRVL
     GGDGEEEGLI DEAAIHLRSY FPQSWMWALL DPDVSGNIRY KDVTPDSITT WEVQAVAMSP
     SKGFCVADPK PLRVFQDFFV SVKLPYSVKR NEQLEVKAVV YNYKKEDLKV KVRMKKADGL
     CSAGEGDVVQ DVSVSGQSAV AVYFTVVPLI IGKIPINVLA YASPSAQDRI QKELRVVGEG
     ELVSIYKEYN IDAKSGVMGE SVDNCLNLDG VDNLIKLPTG CAEQTMVKMS PALHAMKYLD
     GTNQWAFLKA ERRDEAQSMI QAGYTTVLTF KKSDGSYGAF LTRPSSNWLT AFIAKEMTNS
     RSIIQVRDSY IQESMSYLIS KQKAGGSWDD PNPLYDTGMK GGVGQTKDEA PLTAYILIAM
     THAKQAYEQG TDTELITAME KAKSYLVQNF ARLQNPYAVT ITAYALSLIG QTPQEAQQAT
     RKMMEMATCD TKRCFWNVRE AVSGLDSKAD AISIEATAYG LLQAVSLKDK ERALRIASWL
     TQQRKYGGGF QSTQDTVVAL EALSKFSIQN NDVEDLDLRV ELCINDKETK NLHLNKYNAL
     TQAAVQVRGI KEVGEMSLNI NGRGRGTLSI LQTYRSLKKE ESHCDQFHFS VQVDGELEEE
     EQLDDYYNYE SNDEELAKDE PMSREEWFDL RTRRKRQAPE QPKKENILVY TVCVGIKGRN
     SSGMVVVDIS LLSGLTPVIQ DLEDNVKGTE KYIDHYDFHH NKVFLYFDKK DCLRFRVEQI
     IPIGLIQPAA AVIYDYYNPD RRCSTFYTAP KSSPMLSKLC EGDVCMCAEG ACPRMKVTFS
     KNMNKQTRKS YACFSPVVDY IYTVKVLNSS NDLVFTTYST IITNLLQPGK DEGIQRGSYR
     EMIQRSACEE VEMKSDAEYL IMGLDSSISG LRDRFRYILN DKNWIEEIPP ENKCKATRNR
     LACQLLQDFL EQYFTKQCLV Q
//

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