ID A0A3B1J8R4_ASTMX Unreviewed; 3579 AA.
AC A0A3B1J8R4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Bassoon presynaptic cytomatrix protein {ECO:0000313|Ensembl:ENSAMXP00000038677.1};
GN Name=BSN {ECO:0000313|Ensembl:ENSAMXP00000038677.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038677.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000038677.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic active zone
CC {ECO:0000256|ARBA:ARBA00034101}.
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DR Ensembl; ENSAMXT00000037877.1; ENSAMXP00000038677.1; ENSAMXG00000042403.1.
DR GeneTree; ENSGT00620000087961; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000042403; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0048786; C:presynaptic active zone; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15772; FYVE2_BSN_PCLO; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR008899; Znf_piccolo.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14113; PICCOLO/BASSOON; 1.
DR PANTHER; PTHR14113:SF1; PROTEIN BASSOON; 1.
DR Pfam; PF05715; zf-piccolo; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 85..143
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT DOMAIN 335..393
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1579..1632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1879..1916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1956..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2017..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2243..2354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2509..2598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2751..2821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2943..2989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3003..3046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3088..3217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3231..3547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2041..2101
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2142..2169
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2630..2667
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..841
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1163
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1579..1607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1895..1916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2243..2257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2258..2320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2509..2585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2753..2767
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2782..2803
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2804..2821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3004..3023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3088..3103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3118..3142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3143..3160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3191..3216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3231..3249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3261..3281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3309..3333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3334..3363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3377..3490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3579 AA; 387258 MW; A529CDE941047F66 CRC64;
GAARAAFVSM GPKPGGPGGP GGTGPGPGAP QQPPGSAQDH TARKNLQVDV GSSKSGRSPA
ASPGNSAPPS PYALPQIAPM PSSKLCPICK TADLTGTTDG QPNSSTCTQC RSTVCNQCGF
NPNPHLTEVQ EWLCLNCQMQ RALGMDMETP RSKSQQQIHS PSQPSKPQPQ TAPQTPVSAP
VQPQPPPPSQ TPKQPKPQPQ PAQDPHKQPA PDPAKTVPLS KPPAPGAVPL PGLAKAPSQP
DLSRSGPGPP PPEQPFGKLF GFGASLLNQA SNLISVEPTQ APAQGPGPGS APAPAQAQPS
PAKTPQKQPG GPATAPKPSP QATPTQQQKS KPKVTCPLCQ TELNVGVPTE PPNYNHCTQC
HAQVCNMCGF NPTPHLTEKK EWLCLTCQTQ RAMSGDLGGG APPVPQPMGS PRPTGPASQS
ERGPNQQAGL RPTGPQQQKP PSAQVSGPLP PTKQRAQQSK GSTQPSPAKT APSHPASKTD
IRKQEQSVSK KQPMSKTERE GDVKASLKKG TQDVKDQKKN SDMQKSKHHD VSDPLTQSLS
DTGYSSDGIS SSHSEITGLI HEEGVKLSER GISDQRSPPS PSEITKLESS MRPLLESQTG
SDRGRDHHGA DTGDQQRPQS LTISQDQFDS DGEVSDDLSC KLRHDYVEDS SESGLSPMPT
RQKKMQKELT DEEFMRRQIL EMSADEEEMG EAEGHVRVKK SHKHSGDLGK ERRRLTQQSS
SFEEDTKGTD GAYKSSEADD MMGSQGGLRR FKTIELNNTN SYNREMELST EHDLREPELE
MESLTGSPEE RSRGEYSSTL PATTPSYTSG TSPTSVSSLE DDSDSSPSRR QRLEEAKQQR
KARHRSHGPL LPTIEDSSEE DELREEEELL REQEKMRDLE QQRIRSTARK TKRDKEELRA
QRRRERSKTP PSNLSPIEDA SPTEELRQAA EMEELHRSSC SEYSPSMDSE AEGFEMGSKL
YKSGSEYNLP TFMSLYSPTE KTAASPSAMD KSLKSAEEVY EEMMRKAEMM QKQQGQQGRQ
GQQVPPHLAH NQHLGTGTKS LSPGTSPTQV AAPVSFSERG SSGRGKGVNE QQQYAQQNQP
RMASQTSKMG PAHQGPQSQV RQPAPGQTQV RPSQATPTDA GNASLTTKMF SYFKGPSPPT
SPSTSPTQSP TRPRAPGPVS PAPTPQGSHI SQRPGAPRLA RQQSSQDSPV MVITLAGTQS
QQTKPVTVNS STSPLSSPTN NRQQPIYQTQ TPKASSNSSL QQSQQSFQRA QIAERVTVGV
STATTASSQS HKSPVENISL CKISTVPGTS RVIEQGTMAQ SGNVVDLRAP VKPTPIIMTD
QGMDLTSLAS DTRRYSLDSD QPPSRHTAVQ PLIMNLNAQA QPHVTSSTPT TVSVTVAASM
FISQPKHPVV YGDPMQNRVD LGQGVGSAVC LTQTRPQLQQ HQQNTSSFAR YNLANQVQPI
LLKKDLVASQ TSGGGTQTVV SSVTKVSPLP PQSLTGSVSS TPTHGHDIYG GIALELKNKP
TVMNLSSGTP HVMMVQLDES SSSQGGTVTQ IVKNEEPPPP PAPEVLDLTG QIKSENQVAC
CDVVYKLPFA GSCSGPFGQR GKTATSEPNP TPDPTQASHQ QSQPGKDGMT EEPKPFTMPP
PGRIPPSMSD TNLAESGLQY YQRADPGDLA VDLSSMKQAY EQGYLGMGAQ YGSYTDLRHQ
GEVSAPPLPL RRYGSMSNIS GDYGYPARDA AGFQESNLAQ YSATTAREIS RMCAALNSMD
QFGNRYANSP ELLQYGVGRG GPAARLGLQQ GLASIRANLL YGPDGRPTAH GQVLTNLINA
RQASLRALYP PAVRTADGMI YSTINTPIAS TLPITTQPAP VLNPMLRGVY RPYPPGNVTA
VPLASLTRLP AVTPRMPLST QGPYRYPPPN RFPTSSPDSL AGSIPPTSTS QETPVYLGKP
TVPGTMPTST TLPPAQPVTN FQGQCAPIVN ASTSAVPTQP TMLSQQSSQS HIPVNGTIVH
PPSQTQIPIR QQTQPQTHPQ AFTKGQDLSL SQGLSLSQTQ SHLSVPQSQP QADSAASAIM
TTATDKEKEK EEERLRQQQE QLLQMERERI ELEKLRQLRL HEELERDRIE LQRHREKEQM
LVQREIQELQ TIKQHVLQQQ QAERETQLVM QREQLAQQRM QLDQIHSLQQ QLQQQLEEQK
RQKTAAVEAA AAVAAAEAAA ASAAAAAAAT TAQGAIQGIM VGSSPQAISI LCDQNGRVIQ
QDGQSVQFLP CVDGQMMQAL VSARSIPSSA SEMSLRNSDD QRSGRTMKKQ NSMPRLRDDS
EEEPVKRIAD SSVQTDDEDG EDRFMSRRRR TRRIADCSVQ TDEEDQGEWD NQPVRRRRSR
YSKHSESSAE AKADASKVTS SIAIQTTNDS SCQTETEQLG RVSPAIHITM AETSKVELLH
YISAPERTKK GESLACQTDP EAQSQGVVAP QLSVPTTVSP YSTSLQLVGA TPTKFERRKP
DPLDIGLQAQ QQNDARGPPK SPQVLYSPVS PLSPHRMLET TFASSEKLNK AHVTPQQKAF
TTESPQRHQT IPRPIKSVQR SMSDPKPLSP TSDDPSKTKF SLYQNQNSSS SQMSSLQQQN
AMMRKVKRTL PSPPPDETPL PIVTPAMPHM YSSPGMSQRV LPRPVQGITK AGLLSDLKAV
EQESTKLRKQ QAELEEEEKE IDAKLRCLEM GITQRKETMV KERERRELAY LRSMGDARDY
MSDSELNNLR LAGVATGTYD GNAMLSRPST APLNQFTSDL NSASQYLPTS SYLPYPYPQP
SQPTPTQPPA AAYQQIGFQP PQYPAPSQPQ PGTFQPHPPQ PSSYQPQGAF QSHGYSHQNM
SFQPQSDLLS VHQMPRQTSL ADLEQKLPTN YEIISNPAVS VASSAQETGF SGVYSSPLTN
AYAPYRTPDQ TLTDRIPSPT SGYGTEGLYA SNLEQNIPRN YVMIDDISEL TKENMGSSDM
LRAGYGNENG PRGTCYGPED PYGRSADGTG YHQQGGMDSH GRPNASVSGG SSAYYYDDYK
HGSRSSSGMG SQKHSSKNLA PAVVSSKRSK HRKQGMEQKI SKFSPIEEAR DVESDLASYT
MTTSTGGSCT IVSRTGVKKN VYDQQKNYGS RDRLDEDDRL YSSGRSRSTG YGMDKISSRD
SAGHRSKSYE RDAMERSQRG THGRSGRPSM RTQNSEEESP LSPVGKPMGI GRVPDPHDVR
NQYGSSHSLP DVQDHHMRDI PKSQVYKPDD PYLVDDMHCA VSDSEAYHLG QEETDWFEKP
REARSRHHGG GGHSSTGKRS HVKHTYHDYD EPPEEDLWPQ DEYGHQQQSS STSPRDHRHH
GSSSGRHSSS RHSSEDPRSS RSSRSHPKDP SGRSEGRGTS SSSSSSGKRS SDPRSSQSGY
RDSGDYSRDP AAGHHHTSSG QRGQRQSGAS RRQESPGSRQ QQQQQQQQQQ QGPGGQQQPP
QPGQQQQQQR STAQPTTGRQ PGSQQPEPGQ AGQQPRSQQQ QMQQQQPGQQ PATTAGAPQP
TSSATGAGAG AAAAQQQAKP GQVSAPGRQQ AGGPPAPQPA AAGVTAPRPG GIGSAAQPGQ
QPAEGENVLT KILQGGAAEQ AGKLGDAVSA LGKKFTSFW
//
