ID A0A3B1J9U7_ASTMX Unreviewed; 1031 AA.
AC A0A3B1J9U7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 1 {ECO:0000313|Ensembl:ENSAMXP00000039008.1};
GN Name=LRIG1 {ECO:0000313|Ensembl:ENSAMXP00000039008.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000039008.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000039008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1J9U7; -.
DR STRING; 7994.ENSAMXP00000039008; -.
DR Ensembl; ENSAMXT00000045659.1; ENSAMXP00000039008.1; ENSAMXG00000009190.2.
DR GeneTree; ENSGT00940000158502; -.
DR InParanoid; A0A3B1J9U7; -.
DR OrthoDB; 5405965at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000009190; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45842:SF20; LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1031
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017190742"
FT TRANSMEM 792..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 490..589
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 594..683
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 688..774
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 891..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1031 AA; 112924 MW; 184F2EDF810138CC CRC64;
MAASLGQTGP LFRCVLGLFL CLELLISGGL SSEETCASNC TCAGSKTDCS GLKLTHIPAD
LPEHTETLNL SHNKLTAVDT DILSNLPNLR EVRLDHNELT SIPLFGNASA AIVTLYLNYN
KISSVQGSRL ESLKNLKVLD LSNNEIIDLR EHCFPPGLRI RELILSSNKI VHLESGAFRN
LASSLQILRL SRNRLTQLPV KGLELPKLTQ LELSRNRLRL IEGLTFQGLS SLEVLKLQRN
NISKLTDGAF WGLARMRTLH LDYNSLKEVN SGSLYGLESL LYLHLSNNSI SSFNPEGWGF
CERLRELHLV HNNLSKLTEG SFAKLVNLQT LRLSHNTISH IAEGAFRGLS SLRLLELDHN
DISGTIEDTN GAFAGLDSLR KLTLFGNRIK SVAKRAFLGL EGLEHLNLGE NSIRSILPEA
FSKMKNLRSL EILSDSFLCD CQLHWFPEWV VNRGLQAEVQ ATCAHPESLK GTSIFQVPAQ
SFVCDDLPKP QITVHPVQTA GVVGKDVRLT CTAASSSSSP MTFTWRKDQE PLRQAEVENF
AHVRSSDGGV MEYTTVLHLR DITFDHEGRY QCVISNHFGS TYSNKARLSV SVLPSFVKTP
RDITIRAGTK ARLECAATGH PTPQVAWQKD GGTDFPAARE RRMQVMPDDD VFFIMDVKPE
DMGVYSCTAK NTAGMISANV TLTVLETPHL ALGMENRSVV VGETVALQCK ALGNPPPRIT
WLRGEKPLRP SDRHHFTPGN QLLVIGSAAL EDAGRYTCVM SNPLGTERAH CSLSVYQRPS
GPCTLQSGPS TVTVGIIVIA VVTSIVVTSL VWVCIIYQTR RKSEECSVNT DETIVPPDVP
SYLSSQGTLS ERQDICIRVE SSGGSQPSGY RDSNGGFDVP VLCTDCMENS STYSKPSDYL
PHGIAPPSGS EYQQSPPPST FTSHRTGDTH CNGTPNGVRR DPQPIFPSNH DRSLQKKQSD
RRGYSVKKAG TASSPSADES YHHPTKPAPL PPTHTDTECG SELTKTLLPN GHAHTARPAQ
SESAPLRRAS D
//
