ID A0A3B1JA01_ASTMX Unreviewed; 908 AA.
AC A0A3B1JA01;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038139.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000038139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B1JA01; -.
DR Ensembl; ENSAMXT00000036826.1; ENSAMXP00000038139.1; ENSAMXG00000002958.2.
DR GeneTree; ENSGT00940000155991; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002958; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.60.40.1150; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.310.10; TATA-Binding Protein; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF31; AP-1 COMPLEX SUBUNIT BETA-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00185; ARM; 2.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF55711; Subdomain of clathrin and coatomer appendage domain; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 681..788
FT /note="Clathrin adaptor alpha/beta/gamma-adaptin appendage
FT Ig-like subdomain"
FT /evidence="ECO:0000259|SMART:SM00809"
FT DOMAIN 797..907
FT /note="Beta-adaptin appendage C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01020"
FT REGION 512..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 908 AA; 99089 MW; 251F446C995F2958 CRC64;
MNYAKSQPDM AIMAVNTFVK DCEDPNPLIR ALAVRTMGCI RVDKITEYLC EPLRKCLKDE
DPYVRKTAAV CVAKLHDINA QLVEDQGFLD TLKDLISDSN PMVVANAVAA LSEIAESHPN
SNLLDLNPQT INKLLTALNE CTEWGQIFIL DCLANYTPRD DRESQSICER VTPRLSHANS
AVVLSAVKVL MKFMEMLPKD LDYYGTLLKK LAPPLVTLLS AEPELQYVAL RNINLIVQKR
PEILKHEMKV FFVKYNDPIY VKLEKLDIMI RLASQANIAQ VLAELKEYAT EVDVDFVRKA
VRAIGRCAIK VEQSAERCVS TLLDLIQTKV NYVVQEAIVV IKDIFRKYPN KYESVIATLC
ENLDSLDEPE ARAAMIWIVG EYAERIDNAD ELLESFLEGF HDESTQVQLQ LLTAIVKLFL
KKPTETQELV QQVLSLATQD SDNPDLRDRG YIYWRLLSTD PVAAKEVVLA EKPLISEETD
LIEPTLLEEL ICHIGTLASV YHKPPSAFVE GSRGVQHKRL PARAGSGEST ESPDVGQSVS
GVSDAPPAVI PSQGDLLGDL LNLDLAPPTT TVPPVPSSMQ MGAMDLLGGG LDSLSGSHYR
TEVPSPQPAD FSERELGGDL GGSPAMGVGV GVGVGVGVGL GPAPVGMPAG LGAAPAVGGG
LGDLFDLGGG VGMTSGSYSP PRVVWLQAMK AKGLEISGTF ARRGGVIQMD VSLTNKAMSV
MSDFAVQFNK NSFGMAPAGP LQVLTPLGPN QTVEVSLPLS STGPVMKMEP LNNLQVAVKN
NIDVFYFSCQ YPISLLFVED GKMDRQVFLA TWKDIPSDNE AQFQIKDCHL SSDAASNKLQ
GSNIFTVAKR TVEAQDMLYQ SIKLTNGIWV LAELRIQTGN PNYTLSVKCR APEVSQYVSQ
CYELILKN
//
