ID A0A3B1JA93_ASTMX Unreviewed; 1069 AA.
AC A0A3B1JA93;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=WD repeat domain 33 {ECO:0000313|Ensembl:ENSAMXP00000038790.1};
GN Name=WDR33 {ECO:0000313|Ensembl:ENSAMXP00000038790.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000038790.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000038790.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JA93; -.
DR STRING; 7994.ENSAMXP00000038790; -.
DR Ensembl; ENSAMXT00000043658.1; ENSAMXP00000038790.1; ENSAMXG00000019144.2.
DR GeneTree; ENSGT00730000111130; -.
DR InParanoid; A0A3B1JA93; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019144; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR045245; Pfs2-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22836:SF0; PRE-MRNA 3' END PROCESSING PROTEIN WDR33; 1.
DR PANTHER; PTHR22836; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 66..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 107..139
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 149..175
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 193..234
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 236..268
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 280..311
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 424..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..577
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..619
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..710
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..853
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..929
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 115298 MW; 89EE9BCE8CE3B53C CRC64;
MVPPVGMLNN PMNAVTTKFV RTSTNKVKCP VFVVRWTPEG RRLVTGASSG EFTLWNGLTF
NFETILQAHD SPVRAMTWSH NDMWMLTADH GGYVKYWQSN MNNVKMFQAH KEAIREASFS
PTDNKFATCS DDGTVRIWDF LRCHEERILR GHGADVKCVD WHPTKGLVVS GSKDSQQPIK
FWDPKTGQSL ATLHAHKNTV MEVKWNLNGN WLLTASRDHL CKLFDIRNLK EELQVFRGHK
KEATAVAWHP VHEGLFASGG SDGSLLFWHT GVEKEVGGME MAHEGMIWSL AWHPLGHILC
SGSNDHTSKF WTRNRPGDKM RDRYNLNLLP GMSEDGAEYD DNEPNSLAAI PGMGIPEQLK
VAMEQEQTTD KETAPEAEMS IPGLDWGMDE VMQKDLKKAP TKKVPYAKPI PAQFQQAWAE
NKVPALPPGE IPKERKDEKV DGKKKTQAEI EQEMAALQYT NPMLLEQLKI ERMAQLQEQG
VPPSGGQPGS MPPFPGQGGP MAPPPQGFPQ SMPPQQMPPH NMPPMGPGGM QGPFIPQGQM
GPPGPSGPPP HQGPPPPQGM MGPPDLHGPP RHPGPHRNMG PQGPHGMPQG PRGMQGPPPQ
GGIPPAGGMM GPPPRGQGPP QGGMMHQDMR GPAPHGNMMG PQGPMQGGMM GPPPRTHGSM
QGMGSMHGIG PPSGGMHGPP SNMQGPQGNM QGPPGNMQGP PPPYMQQGKP PPPQHMGDGS
RGQFNQGQNS GPQTMMHGPG GKDGPRGPPN HHMGPPDRQG PGAGAGPGQA SDAGSQYWGE
EGGFQENWRR GPGGPGQEYH GDPRGHRGSS GGQWENQERF SSHDGEYDRY DSYEGQGEEF
DQRQRRPQED SYRRGGPSGR GGRGSYQDDY GGDDSFDSQE EMSQGWGNGG RGRRGGPPRG
GGVGRRGLLP TPDEEEEEEE EEEDYEDYGL YSEGGGGGSQ EGWEGGRDSG HDGYRDSQRG
DHSMHDSQSA ASRERSSSLQ GMDMASLPPR KRPWHDGPGT GDMDSPGSGP DDRGSGRPPR
DDGGYGPPSR GGRGGWGRGG PPNPGGPGGA GPNSRRGGTR GALRGGRGR
//
