ID A0A3B1JAA1_ASTMX Unreviewed; 698 AA.
AC A0A3B1JAA1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Centromere protein U {ECO:0000256|ARBA:ARBA00016402};
DE AltName: Full=MLF1-interacting protein {ECO:0000256|ARBA:ARBA00031456};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000039242.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000039242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-U/AME1 family.
CC {ECO:0000256|ARBA:ARBA00010440}.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; A0A3B1JAA1; -.
DR STRING; 7994.ENSAMXP00000039242; -.
DR Ensembl; ENSAMXT00000048201.1; ENSAMXP00000039242.1; ENSAMXG00000034083.1.
DR GeneTree; ENSGT00940000153232; -.
DR InParanoid; A0A3B1JAA1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000034083; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.30.70.1470; Caspase-like; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR025214; CENP-U.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR32222; CENTROMERE PROTEIN U; 1.
DR PANTHER; PTHR32222:SF1; CENTROMERE PROTEIN U; 1.
DR Pfam; PF13097; CENP-U; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 465..589
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 604..698
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..365
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 77706 MW; F45BA1A6F41A94A9 CRC64;
MSRVTRMVKG VQKELKKRNQ KPVLNEDLED LDGLDVSSIE KASFLQEEQF SSHGNPLHST
ALEDGCSPEL SSHPQAAAGR KETEKGQKKK QHVTETPKRP ARVEKGQAKT KHKGEIHSQQ
KISGSKANQK PTQKVKQGLK SRRLQTILEN KGAEGKKKAQ TEVHKDPTNE GAEADTSPDA
TPAQSQRRPS ISSEEVTDED ESFHPSKQKR KSSEGRQRGA RTSSGQQQKG QKQKRKSSSG
SSDGGNLRKK QKHEAVKNPI DLDIVLEAFQ DFVAQYKETV DSDSVKKAID AFSSSFEEQL
SEMITATKEM NDVKRTAVKI NSTLNHKKTK LLEAKNELIK SEDDVRKLQK EHDELQQRLQ
ALRQGTSFLT NLKALNQRYL DYRIAHPDEP ETYGPSCMPA MLMEARSITE TMADEENGSK
AAEGGDSVDA KASNPKGSET VHTASVPAKS KAPVDMFRYR MDYPNLGKCI IINNRNFDRS
TGMSDRAGTD VDAGKMLKVF SELGFKASVQ NNRTVSQMRQ ILTSASKEDH SKSAMFVCVM
LSHGDEGTIF GTDGCMELKE LTRLFRGNQC PSLAGKPKLF FIQACRGSEL DPGIETDSVD
DSEGTHKIPV EADFLYVYST APGYYSWRNT ANGSWFISSL CEMLAKYGRE LEIMQIMTRV
NHKVALEFES SSNTPGFNAM KQIPCIMSML TKELYFPK
//
