ID A0A3B1JB95_ASTMX Unreviewed; 677 AA.
AC A0A3B1JB95;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein {ECO:0000256|ARBA:ARBA00040699};
DE AltName: Full=APBB1-interacting protein 1 {ECO:0000256|ARBA:ARBA00042746};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000039136.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000039136.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MRL family. {ECO:0000256|ARBA:ARBA00038382}.
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DR AlphaFoldDB; A0A3B1JB95; -.
DR STRING; 7994.ENSAMXP00000039136; -.
DR Ensembl; ENSAMXT00000052384.1; ENSAMXP00000039136.1; ENSAMXG00000029790.1.
DR GeneTree; ENSGT00940000156105; -.
DR InParanoid; A0A3B1JB95; -.
DR OrthoDB; 3144731at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000029790; Expressed in mesonephros and 14 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16137; RA_MRL_RIAM; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243:SF14; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 178..264
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 308..417
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 17..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..520
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..633
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 74084 MW; 8E5BCA8BED564FC4 CRC64;
MDDIDAMFTD MLEEMDLLTQ SLGAEATEPT PPSKSSSSSS FNSMPEMSNF SIGFTDLNAS
LNELEDNDLD SLMADLVADL NATEELFAAE KGGVKEPRPP PAVTVPAVHF GSAAPIAPAA
PTPSKPKNDV TSCPPAGNTQ SLPPPPPAST RPSTDDPEAQ KAEKIKLALE KLKEAKVKKL
IVKVEITDGS SKTLMVDERQ TVRDVMDNLF EKTHCDGNVD WCLCETNPEL QTERGFEDHE
NLVEPLSAWT RDSENKVLFH ERKDKYEVFK NPQNFYMWKK DKKSLMDMKD KDKELLLEEN
FCGTSVIVPD LEGMMYLKEE GKKSWKQRYF LLRASGLYYL PKGKTKSSKD MVCLVQFDNM
NVYYCSEYKT KYKAPTDYCF ILKHPQIQKE SQYIKYLCCD DKWTMTLWVT GIRIAKYGKT
MYENYKTAAR KGSSLSAVWT SMNRQPSPST SNTSTPSPTP KAKTANGHAS QPRSETVPKA
PSNQSAFPPP PPPADFLPPP PPDPTLPPPP PPPPALPVKK ESNPPRSAPQ RSQPAFPPPP
PAMDFSLPPP PPPSDDLEMP PDFLPPPPPA PGGFMGGDLL PPPPPEPFHA PLPPPPAAFH
PPPAVHPPPQ ATGGDLPPPP PPPPPPPPAP AAFHQTPSVR KVGPPPPKRT TPSLAAPSGG
DFMSELMLAM NKKRGGQ
//
