ID A0A3B1JC57_ASTMX Unreviewed; 778 AA.
AC A0A3B1JC57;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ssemaphorin 4F {ECO:0000313|Ensembl:ENSAMXP00000039435.1};
GN Name=SEMA4F {ECO:0000313|Ensembl:ENSAMXP00000039435.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000039435.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000039435.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B1JC57; -.
DR Ensembl; ENSAMXT00000037800.1; ENSAMXP00000039435.1; ENSAMXG00000017198.2.
DR GeneTree; ENSGT00940000159592; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017198; Expressed in bone element and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045791; Sema4F_C.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF72; SEMAPHORIN-4F; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF19428; Sema4F_C; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..463
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 643..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 85568 MW; 12C751C37934A65A CRC64;
MVSGLDFAGV GNFSTFLLDR SSGMLYLGAR DAIVAVDTAN LSKRLKIVWS VPEDKRKSCV
AKGKTEADCN NYIRLLEFLG DGRIYACGTY AFDPQCAFVN ISSFSLEKLE DNSVRMETGK
GKCPFEPSQH YTAVMAGGVL YTAATSNFLG TLFDISRATG PEQERIRTER SINWLSDPEF
VSSAFIQENE KNNPTGEDDK IYFFFTEVAK EYDLYTKVKV PRVARVCKSD IGGMKTLQRR
WTTFLKAQLV CEDRASGQRF NVLTDVFTKQ HQPGDPSSTH FYGIFTSQWE REEMSAVCVY
SLEDISKVMD GPFKELKKSC ENWMNPEPVP SPRPGQCLNN ALKTEGFESS LKLPDKVLTF
MRDHPLMENS VVSVPLLVRS GVTYTKLAVT LTTVSNGNTR QNATVLHLGT DRGELHRVAV
VGQNATLMQE LPLFPAAEPV NNILLNKGKA IVGSPHSLVR LPAEGCSLYT TCEECARART
LGCVWRQKEG ACDLAVTEPG EGVEPEYSDS QCGNGEDRCS PATTELRVVE GLRVLLSCVQ
VSPRPCHWKY PPQRHARRHH SDLEVRVTPE SLGNYECVCE EAGRDQPPCR RAAYSLTLEE
PVTGSNTGQT GSRHFVVGYL LFFFIGFSLA CAIFIIRLRR SKRGGGHSSS ISEKGRDLLP
SSDTPQSPSS ASLLSEAVPF TEKRNGTLNG HGNHGGHMIV QNCTHIYSNS SGLKLQESAV
NLAEELDGRE RAGPEGEEEG LGEGLSELGD GLVGLEEEMA KLQVLRGAPL AQCEESSI
//
