ID A0A3B1JG33_ASTMX Unreviewed; 777 AA.
AC A0A3B1JG33;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SH3 domain containing ring finger 2 {ECO:0000313|Ensembl:ENSAMXP00000040780.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000040780.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000040780.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH3RF family.
CC {ECO:0000256|ARBA:ARBA00008649}.
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DR AlphaFoldDB; A0A3B1JG33; -.
DR STRING; 7994.ENSAMXP00000040780; -.
DR Ensembl; ENSAMXT00000045607.1; ENSAMXP00000040780.1; ENSAMXG00000041131.1.
DR GeneTree; ENSGT00940000155875; -.
DR InParanoid; A0A3B1JG33; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000041131; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd11787; SH3_SH3RF_2; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14167:SF84; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00184; RING; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 11..55
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 180..245
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 378..439
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 714..775
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 246..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 84391 MW; 1B302CA6A85DF825 CRC64;
EDVGVLDLLE CPLCMEPLEV TARVLPCQHT FCKPCLLRLE LSSPSRLPIC CPECRAPLSG
RVEDLPTNLL LARLIQGLQR ERLTTPRNRG GVCVSSTAQD GSVVEVLQPV QQQTGQSTQG
VLAKASYNYQ SNGPGELAMK SGDIAGLRWR ADENWWHADA KGSGGVIPTK MVQVLSDQAQ
PVALCRALYD FDVNRLDPED RKECLPFLKG DLISVIKRVD ENWCEGRLRD RVGIFPLQFT
EPNPTALKLL GRGKGVDGAE SRPQDTRQSR GRRRVSATTR PPQVSLLNSL NSRPVYGHAQ
SQHPQYSGPA APPPPPAQGK AAQLGPASKQ RTGGSARRSL SKGERKMNGE APPTITMALI
NPQAPPPPPE SKQSSTQQLS ISCAALYSYS PHRPEELELR KGEMVGVYGK FKEGWLRGLS
LRTGKVGILP ANYVTPVLTS ARFLEQPKPA APIASAPVST KRYTHQKPQA VVLALDKVKT
DGTSAAPVIA MPPQPAVSSG GASRAPQAGG KPGWDTVRRA FQPSHRSPHR NSYHSQSAAQ
SFQPPPQDLG QIYGFGRSPV LPRKRNGLFT NPMKPQHWTS EGLTPSGGGY YTMDAKYSLP
KETSTSPQSI LVKPDSYKYN TEKPVKTVRF STEELPQTTP RLSSLSSGTQ IMGNSQSSSA
ALEHWNPSAI LGRDGSTSVL KDTKTLLQRK GPAQNHSTVD GLPLTIKPPI INSQSSPSHR
VLMGYNAQTD AELNLLEGEL VLVQRPRLDG RVLVTQEITG RTGLFRNSIL DILDKVV
//
