ID A0A3B1JIN5_ASTMX Unreviewed; 527 AA.
AC A0A3B1JIN5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=VWFD domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000041169.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000041169.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JIN5; -.
DR STRING; 7994.ENSAMXP00000041169; -.
DR Ensembl; ENSAMXT00000056534.1; ENSAMXP00000041169.1; ENSAMXG00000035750.1.
DR GeneTree; ENSGT00940000163235; -.
DR InParanoid; A0A3B1JIN5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000035750; Expressed in intestine and 9 other cell types or tissues.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF401; INTESTINAL MUCIN-LIKE PROTEIN ISOFORM X1; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF00094; VWD; 2.
DR SMART; SM00832; C8; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 48..206
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 348..417
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 527 AA; 57913 MW; 4FC808F3CDE6C616 CRC64;
MARCIEDNII EIIPYECPPL KNITCSNGKK PVLVWDENYC CEEYACDCFC EGWGDPHYKT
FDGHFYSHQG NCTYFVSCPR ALIVSYNGVV ITLRNNNLIG AAKLEALFGH TSLKLPFAKN
GLRVLGTGVK MIVEIPQLEA VLTFGVTGFS VNLPFRHFGE NTQGHCGTCN NNKNDDCMLP
GGKLIDDCAV MADYWPAKDL YNPDCPQPPT VPPTSAPTKK PCPANTVCEL LKTDLFKECH
PYVSPDNYFT GCQFDSCHVT NPAVVCTSLQ TYASACSQFG VCLHWRNHTN LCTVSCEGNK
VYKPCGPAEP PTCQDKYSMN VTTEGCFCPD GTMLFNKDSG VCVDKCGCLD PSGQARELGE
KFEHNCQDCI CEAATASVTC QPKQCSNSNP VICNEPGFIV ANETDPTDEC CTIFTCRCDS
SLCPSVDGKC NIGYAPVLTV PEGKCCPELR CDPKKVCVHK NIEYEVNMSD TSLTLKTLTY
SCYLSSAIFV KKYGTLSIAI SIIHLLEQCN FSHTITKYVL LTSYLAK
//
