ID A0A3B1JIU1_ASTMX Unreviewed; 416 AA.
AC A0A3B1JIU1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dynein axonemal assembly factor 4 {ECO:0000256|ARBA:ARBA00024430};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000042253.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000042253.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Dynein axonemal particle
CC {ECO:0000256|ARBA:ARBA00024190}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B1JIU1; -.
DR STRING; 7994.ENSAMXP00000042253; -.
DR Ensembl; ENSAMXT00000050726.1; ENSAMXP00000042253.1; ENSAMXG00000040241.1.
DR GeneTree; ENSGT00390000004930; -.
DR InParanoid; A0A3B1JIU1; -.
DR OrthoDB; 167568at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000040241; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003341; P:cilium movement; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd06469; p23_DYX1C1_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR037894; CS_DYX1C1.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46492; DYNEIN ASSEMBLY FACTOR 4, AXONEMAL; 1.
DR PANTHER; PTHR46492:SF1; DYNEIN AXONEMAL ASSEMBLY FACTOR 4; 1.
DR Pfam; PF04969; CS; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 3..87
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REPEAT 362..395
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 172..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..171
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 47500 MW; 5FA8C3D12099771D CRC64;
MPLLVTDYSW TQTESTVYIS VPLKGVKPAR VDVLCTDEYL KVSFPPFLCE LFLSQPVEEE
KSVAKLGNGA AVFTLPKQTA GLWEKLSRDV DKSKQREIRE EAILKTQNKA VETTKARATK
IQQDKKYTLE TMMKLEEEER ARIQKIKDEE CAKASMELEA WKKNQRRLAE EEEARRRLQE
PPVQKSRPVH QQREPEKACV MRASNNPSKT EGQTTSRNMQ KQKDLPPPRS AGCIKISFTP
RVFSTALRES RVPEEEEWLR KQAEVRRMAN ADLAQLDDLK EEEKNPDWLK DKGDKLFRTG
NYQAAVNAYD LAIKLNRRIP ALFSNRAACH LKLRNLHKAI EDSSQALELL TPAVTDNAAA
RLKAHVRRGT AFCELELYVE GLQDYHAALK IDPNNQALRA DADKIREIIQ GTMSSS
//
