ID A0A3B1JJA0_ASTMX Unreviewed; 1006 AA.
AC A0A3B1JJA0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=B30.2/SPRY domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000041925.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000041925.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JJA0; -.
DR Ensembl; ENSAMXT00000040087.1; ENSAMXP00000041925.1; ENSAMXG00000020988.2.
DR GeneTree; ENSGT01100000263476; -.
DR InParanoid; A0A3B1JJA0; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020988; Expressed in pharyngeal gill.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 143..275
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 807..1006
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 1006 AA; 113391 MW; 701B58C05D7C5051 CRC64;
LNTGSLAPAV FRPLATWLAP MGMTSNTASN IIGDIEKPIE LQTSNCCQHV ANPSIAKLLH
RLLKYLATMV NIQSEMQTQQ SSLLKEIYTE LYITEGGGGD VNQEHEVKQI EAASRKKPTQ
ERPIKCNDIF KPLPEQNPYR PIRTVLTKGV AGIGKTVSVQ KFILDWAEGE VNQDVLFIFP
LPFRELNLMK EKKLSLVSLL QSFFPETQDL KPRHYKSYKI MFIFDGLDEC RLPLDFQNNE
NLEDIEEQTS VDVLLTNLIK GNLLPSALLW ITSRPAVVSQ IPPECVDQVT EVRGFSDPQK
QEYFSKRIRD QDLANKVFTH IRSSRSLYIM CHIPVFCWIT ATVLERMLSE AESGEIPKTL
TQMFTHFLIF QIKYKNQKYS GKSDTDPQQT RESILALGKL AFQQLEKGNL IFYEEDLRES
GIDIKEVSVY SGVCTQIFRE EHELHLGKFL AALYAFLNSK LPKEQSPEQQ TSKFFKLFSR
STMSQFLNRA VDRALQSESG HLDLFLRFLL GLSLESNQTL LQGVLTHTQR ISHSKETVRY
IKKKIEENPS PEKSINLFHC LNELDDHSLV QEVQKYLSGG GDRHLHQARL SPAQWSALAF
VLANSEEELD EFDLSKCEQS QECFLRLLPV VEISRRAVLA SCNLGVNTCE TLGLVLKMEN
SSLKELDLSN NDLQDLGVEL LSAGLKSSHC KLQILRSVVL MCESLGSVLK LENCCLKELD
LSDNDLHDLG VKLLSAGLKS SHCKLQTLSL SGCMVTEKGC HYLASVLSSN PSNMKALDLT
YKNPGESGMN VLSARLKDPD CKLETLRMKH GGNIRIKPGL KKWFCDFTLD PNTVNPRLSL
SEENRRVEWR EKLQSYPDHP ERFNRCLQVL SREGVTGRCY WEAEWSGGGA EVALNYKTIS
RKGDGSDCVF GENINSWSLN CSDNSYSVYH NDNSTELPPP PSGCRRVGVY VDCPAGTLSF
YSVSSDTHSP SHTLTHLHTF YTTFIQPLYA GIGVYSGSSV TLCKID
//
