ID A0A3B1JJX9_ASTMX Unreviewed; 832 AA.
AC A0A3B1JJX9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Pleckstrin and Sec7 domain containing 2 {ECO:0000313|Ensembl:ENSAMXP00000042707.1};
GN Name=PSD2 {ECO:0000313|Ensembl:ENSAMXP00000042707.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000042707.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000042707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A3B1JJX9; -.
DR Ensembl; ENSAMXT00000049724.1; ENSAMXP00000042707.1; ENSAMXG00000036801.1.
DR GeneTree; ENSGT00940000159674; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036801; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF329; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 375..578
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 628..741
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 769..796
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 56..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 92167 MW; 7E2D2C1CEC25716E CRC64;
MSQEGQGDPL HADTPPPEML AQAQEKAEIP ETGDVEQVNM ENDVKGVNGS ECECEAEEQV
NGDDGEMEAD SEDARPEEEH IGDVLANGDV EGERTEEEQI AEDSKKNGDS ESCCLQAESD
HSIGDSANVP SSECGGLGVP PPPSDQPSED SAEPQDPVRV QNGTGEDSEG QEEDEGCDEE
PARGNVDKFS STFELSVEET DAEVEEEEEV QNQDSFSSAF ERIVEQASGS VALEDEEEDA
GEEEQDRTKE TQDGFSSTFE RIVESELLRG GTCYSSLDSL DVLSLTDETD SCVSFEAPLT
PLIQQRALVG PEPPELELET VQEGAETQEG EGEGDNGMDE AGSGSPLRTS IPGSRSENVL
SQPAQWSIPN GFHNDLPVNR ERSGILPSSV SDANLTDGLC DSELGSLETL ERGSTDTLAN
GCRADADASK RLAKRLFYLE GFKRCDVARH LGKNNDFSQM VASEYLSFFD FTGLSLDRAL
RNFLKAFPLM GETQERERVL VHFSKRFCHC NPEALTSEDG AHTLTCALML LNTDLHGHVN
IGKKMSCQQF ISNLDGLNDG KDFPKELLKV LYNSIKNEKL EWAIEEEELR KSLSELVEDQ
CEAGGKRVVR VTDGSNPFIA IPLLLNAATY KHGILSRKSH ADMDGKRTPR GRRGWKKFYA
VLKGMILYLQ KDEYKPDKDL SEVDLKNAVR VHHALATRAN DYSKRPNVLK LKTSDWRVFL
FQAPSEEEMM SWIFRINLVA ALFSAPAFPA AIGSMKKFCR PLLPSSTTRL KEEEQLKCHE
SKLKQISLEV EEHKKSPPEL TPKSKETEEY RIKEHYLTYE VSNLLSHSRL PF
//
