ID   A0A3B1JK81_ASTMX        Unreviewed;       658 AA.
AC   A0A3B1JK81;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=AIG1-type G domain-containing protein {ECO:0000259|PROSITE:PS51720};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000041709.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000041709.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC       IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
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DR   AlphaFoldDB; A0A3B1JK81; -.
DR   STRING; 7994.ENSAMXP00000041709; -.
DR   Ensembl; ENSAMXT00000036158.1; ENSAMXP00000041709.1; ENSAMXG00000035621.1.
DR   GeneTree; ENSGT01100000263541; -.
DR   InParanoid; A0A3B1JK81; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000035621; Expressed in pharyngeal gill and 2 other cell types or tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01852; AIG1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR006703; G_AIG1.
DR   InterPro; IPR045058; GIMA/IAN/Toc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10903:SF62; GTPASE IMAP FAMILY MEMBER 2-LIKE-RELATED; 1.
DR   PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR   Pfam; PF04548; AIG1; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   PROSITE; PS51720; G_AIG1; 3.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          14..215
FT                   /note="AIG1-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51720"
FT   DOMAIN          253..446
FT                   /note="AIG1-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51720"
FT   DOMAIN          450..651
FT                   /note="AIG1-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51720"
FT   REGION          447..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  74640 MW;  F3A525CC7ED59431 CRC64;
     VLSQIYHALS QINSPLLTVV LVGKTGEGKS ATGNTILGKE VFKSEASAGS VTRDTERVDG
     MVQGRKATVI DTPGLFTISM NEETMEKEID RCLQIIPQPF GIHAVLLVMS LAGRFSQEDK
     EAVEWIKKNF GEESVKYTII LFTKPENLYG MKLEDYIKTS QVLLDVVESC GGRYHAVNNM
     INDPTQVTEL LQKINNMVQN NEGKMYTNEI FSKGGCGDFL RFSFTHLIKE KKNKRPFKHQ
     LGPKMFLDQL LITMDLRMVM LGNAGVGKTA TANVILGRET FRETETTECE LQRGRVDDRN
     VSIIDTPGIN SATLSSEQLK TEMRRLFSLS DPGPHVFLLL IRVGNFTEDQ RSTVEWIQEN
     FGEEALKFTM LLFTGREEMT GSQWKKFSEE NRFLEFVAQF GGGYDVINSK KEANPAQITK
     LLNKIEKMIQ HNRGQYYTNE IYQKTQRKNM KEEEKRSKEG VEMGKSAAGN TILNKEVFKS
     EPGAESVTTE TKRVDGMVQG RKTTVIDTPG LFDNKMNKET LKKEIDRCLE IIPKPYGLHA
     ILLVMSLAER FTKEDKEAVE WIKKTFGEEY VKYSIILFTK ADQLKGRKLC DYIKTSQVLQ
     NVVKSCGGRY HAVNNMIKTP TQVTELLQKI NNMVQNNGGK LYTNEIFSRV QKQLRAKT
//