ID A0A3B1JKK5_ASTMX Unreviewed; 792 AA.
AC A0A3B1JKK5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho GTPase activating protein 10 {ECO:0000313|Ensembl:ENSAMXP00000041839.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000041839.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000041839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JKK5; -.
DR STRING; 7994.ENSAMXP00000041839; -.
DR Ensembl; ENSAMXT00000055131.1; ENSAMXP00000041839.1; ENSAMXG00000040905.1.
DR GeneTree; ENSGT00940000159559; -.
DR InParanoid; A0A3B1JKK5; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000040905; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF5; RHO GTPASE-ACTIVATING PROTEIN 10; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 405..589
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 646..756
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 734..792
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 637..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 89120 MW; 8C340A89BE0DAEB8 CRC64;
MGLHPLEFSE CYLDSPSFRD KIRAHEAELD KTNRFIKELY KDGKNLINAT KQLSMAQRKF
AQCLGEFQFE YIGDAKTDDE KCIDDSLQEF SSFLRNLEDQ RELMMRNITE TLMKPLEKFR
KEQLGSAKAE RKKYEKETEK YYTSLEKLLN MSAKKKEPQL QEADMTVEGM RHHFQEESLE
YVCKLQEIQE RKKFECVEPM LAFFQTVFTF YHQGFELAKD FDHYKRALQI NIQNTRSRFE
GTRSEVVELM KKIKEAPQEY RQTSPISSEG YLYVQEKRPP PFGSSWVKRY CTFVKEQKIL
HMVTFDPKSG GKLGETESVT LKSCVRKTTD TLDRRFCLDI EITDRPGTVL TVQALSEDDH
KFWMQAMGGK EPVHYLGRTY SKERGISTLF SNFWSAPGLA RTVDAQLDEN GVNFVRNSIN
AIETRGINDQ GLYRVVGVSS KVQKLLSLMI DEKSSDVDLA VCEEWDVKTI TSALKLYLRS
LPEPLMTYGL YKEFIVPAKG VSPEARVQAI HCLVHKLPEK NQEVLSLVTK HLANVAAHSK
QNLMTVANLG VVFGPTLMRP QEETVAAIMD LKFQNIVVEI LIEQHEKIFG DAPSTCPASA
ISPLAPTRQS KKQSRQSRPL AVYNPQVLDI HTVSVSPSSE GVSLAPDEAS LGSNESVSSQ
SSTASVSETP PEKSKNSLSC TLPITASQNS GGSTAMASWM NSTFSPSTPE PGSEGSEEAA
TAAGGHEDKP AESVTQMKAK AVYSCEAEHD SELSFQVGAI FTDVTPSREP GWLEGELEGR
RGLIPENYVE ML
//
