ID A0A3B1JKZ4_ASTMX Unreviewed; 175 AA.
AC A0A3B1JKZ4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cyclin-dependent kinase inhibitor 1-like {ECO:0000313|Ensembl:ENSAMXP00000043008.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000043008.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000043008.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR AlphaFoldDB; A0A3B1JKZ4; -.
DR STRING; 7994.ENSAMXP00000043008; -.
DR Ensembl; ENSAMXT00000041946.1; ENSAMXP00000043008.1; ENSAMXG00000038980.1.
DR GeneTree; ENSGT00940000159918; -.
DR InParanoid; A0A3B1JKZ4; -.
DR OrthoDB; 692679at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000038980; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:InterPro.
DR GO; GO:0072331; P:signal transduction by p53 class mediator; IEA:InterPro.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR InterPro; IPR029841; CDKN1A.
DR PANTHER; PTHR46778:SF2; CDI DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46778; CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED; 1.
DR Pfam; PF02234; CDI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 30..77
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
SQ SEQUENCE 175 AA; 20091 MW; 6269F539E1798323 CRC64;
MAMMSSQCDH GELDRGEEDV KPRVAAVRRN LFGPVDHQQL QQDFQRLLCM SMEVAKQRWN
FDFQSERPAS GAVEWEEMRC QDVPAFYRSC VVRAGASKCR LESQTPVSSD RGALVASVAQ
EEYLELRASG AFRGAKLEKR RKLKPLGVKH RQATITDFFT VKKRRFLHQK VSSRQ
//
