ID A0A3B1JL94_ASTMX Unreviewed; 685 AA.
AC A0A3B1JL94;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSAMXP00000043162.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000043162.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000043162.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR AlphaFoldDB; A0A3B1JL94; -.
DR Ensembl; ENSAMXT00000033911.1; ENSAMXP00000043162.1; ENSAMXG00000033143.1.
DR GeneTree; ENSGT01030000234598; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000033143; Expressed in intestine and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 106..192
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 294..502
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 563..680
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 685 AA; 75445 MW; 355A84F7DECE309E CRC64;
MKIQENLRKL TEVPHMATTP GDEATVEYML KRWQDKDSGL DAAWREDYRV YLSFPKKDTP
NTVTVVSPSN AVLFKAQEKE KAYTPDQEDP EVVQPYAAYG PAGHARGKLV YANQGKVSDY
ELLNRTLDLS GTIAIVRYGG AGRGAKAINA APFGVVGVLV YTDPYDINDG LMSDENETYP
HSWYLPPSGA ERGSFTSDFG DPLTPYLAAK KDTYRIPEEN INGAPPIPIQ PIGFGDAQAL
ICELGGSAAP TDWQGSFPCT YNFGGPGFRD ASTYRDSEVK LDVYNAGELR NSTNVMGVIW
GSVEPDRYVM YGNHRDSWVH GAIDPSSGTA VMLEITRILG EKVKSGKWRP RRTIIFGSWG
AEEFGLIGSA EYAEEYISKL SQRAVAYINV DISVFANATL RASASPIAQN VIFTASKQVN
AAGSSSVSVY DNWLKYFNRT SPTYGLIPNV GYLTGAGSDY APFIHYMGIT SMDLSYTYDR
SKTRARIYPA YHTAYDTFDY ASKYIDPGFT SHQTVARTAG NILLRLADSL LLPFNCTDYA
ESLEGYLTGT VENFEELLKA NGISTEPLKE AVKSFRNAAA NLDRVIHSSD LLNETPLKAR
RINDQLMLLD RAFVDPQAFP NKYAYRHVIW ASRTSGVATF PGLADAVEKA RTTGLKEDWA
EAHKHLSIVT QAISGAAHTL TEVHQ
//
