ID A0A3B1JM40_ASTMX Unreviewed; 904 AA.
AC A0A3B1JM40;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 2b {ECO:0000313|Ensembl:ENSAMXP00000043393.1};
GN Name=IQSEC2 {ECO:0000313|Ensembl:ENSAMXP00000043393.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000043393.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000043393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR AlphaFoldDB; A0A3B1JM40; -.
DR Ensembl; ENSAMXT00000042202.1; ENSAMXP00000043393.1; ENSAMXG00000040646.1.
DR GeneTree; ENSGT00940000159667; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000040646; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF314; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 410..603
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 163..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 101575 MW; EAD84A5C5C3D4DF0 CRC64;
QARVYYYLVQ QDSEVSESSP FSDSSKAPYV HRVDFYNDSG CGPPGSRGPV VAPPSPASLA
WAQRTRNQPA SLALRKQEEE ENKRCKALSE SYELSTDLQD KKVEMLERKY GGYFLSRRAA
RTIQNAFRQY RMNKNFERLR SSASESRMTR RIILSNMRMQ YSFDDRQPQP QPPTHHSTGM
GAPHLPDMEP GPPSRPGDYT HLEDSFSKQV KSLADSIDDA LTCRTSREDS QEGIGDSSGV
VDDFGECIWS SSSHPRDTEG GGSSNSRRST PCTECRDYRL RGAHLPLLTI EPPSDSSVDM
SDRSDRGSLG RQLVYEQDSA GGSPQGTLKH NPNARSATSG TAQGQARPAA RPFSPRPHGD
NDSLNSTTNS NETINCSSGS SSRDSLREPL PPLGKQTYQR ESRHSWDSPA FDNDVMQRRQ
YRIGLNLFNK KPEKGIQYLI ERGFVSDTPV GIARFILERK GLSRQMIGEF LGNRQKQFNK
DVLDCVVDEM DFSGMDLDDA LRKFQAQIKV QGEAQKVERL IEAFSQRYCV CNPALVRQFQ
NPDTIFILAF AIILLNTDMY SPSVKADRKM KLDDFIKNLR GVDNGQDIPR DLLVGIYQRI
QKWELRTNDD HVSQVQAVER VIVGKKPVSI YVLSLPHRRL VCCCQLYEVP DPNRPQRTGV
HQREVFLFND LLVVTKIFQK KKTSVTYSFR QSFPLVEMQV HMFQNSYYPH GVRLTSAIPG
GERKVLIVFN APSLQDRTRF VSDLRESIAE VQEMEKYRVE SELEKQKGVM RPSLLSSSVV
GGGVGGVKNE VVNGTIGRPS LDDNYSPGEG LKRTALSSSL RDLSDSGKRG RRNSVGSLDS
TMEVSLSGAE VCIFSFRPKT HHQSDHHPNH LACLPGEHLP YHHQRKNKHG PALHVSTPPT
ESEP
//
