ID A0A3B1JMP7_ASTMX Unreviewed; 1061 AA.
AC A0A3B1JMP7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSAMXP00000043598.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSAMXP00000043598.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000043598.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000043598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JMP7; -.
DR STRING; 7994.ENSAMXP00000043598; -.
DR Ensembl; ENSAMXT00000046720.1; ENSAMXP00000043598.1; ENSAMXG00000004272.2.
DR GeneTree; ENSGT00940000158642; -.
DR InParanoid; A0A3B1JMP7; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004272; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 544..735
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 764..868
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 945..1042
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 396..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 649..676
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 396..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 122178 MW; 5D66FB7B11AC383D CRC64;
MGEIEGTYRT LQTPGTRLGS QFNAGISTLE PGQSLSTAMG SGGKGHCKGL QIRVQGLDDA
QEFFDLESKA DGQTVLTDVY RRINLIESDY FGLEFQNLQM NWVWLEPTKL IVKQVRRPVN
TLFRLSVKFF PPDPGQLQEE FTRYLFSLQM KRDLMEGRLY CTENTAALLA SHLVQSEIGD
YDEVADREFL KLNKLLPHQE HLQDKIMELH RRHLGQTPAE SDFQVLEIAR KLEMYGIRFH
PAADREGTKI NLSVAHMGLL VFQGNTKINT FNWSKIRKLS FKRKRFLIKL HPDVHGPHRD
TLEFLMASRD QCKIFWKSCV EHHSFFRLLD QPQPKSKAIL FTRGSSFRYS GRTQKQLVDY
VRDSGLRRTS YQRRNSKIRM STRSLATDIP KQNLSFNNSL RTASPSSATV SFHSLHSPSS
PVRMMETLSQ TQLQQSQPQL HQNQLQHQQN QQQQLRPPSP VKEEPLKTNP PPNYAFPGPV
IDSPQISPFG SKSALCMSPS FQMSTLSLPG QAPSPLQSPS LNEVGTARLE VEDEVRRKRY
PTDKAYFIAK EILMTERTYL KDLEVITVWF RSAVIKENAM PEGLMTLLFS NIDPIYEFHR
GFLKEIDQRL ALWEGRSNAH VKGDYQRIGD VMLRNMCALK EFTSYLQKHD EVLTELEKAT
KRVKKLETVY KEFELQKVCY LPLNTFLLKP IQRLMHYKLI LERLCKHYSP EHKDHHDCRE
ALKEVAEIAA QLQSSLIRLE NFQKLTELQR DLIGIENLTA PGREFIREGC LYKLTKKGLQ
QRMFFLFSDM LLYTSKGVTA TNQFKVHGQL PLHGMILIVL DAPVEESENE WSVPHCFTIY
SAQRTIVVAA SSKLEMTKWI EDLNMAIDMS KKSQEKSDLL LDPSLCDRSN RSSDEVSLEQ
ESEDDVNSSR CSLDKQSHHR ANTTMHVCWH RNTSVSMSDH SLAVENQLSG YLLRKFKNSN
GWQKLWVVFT NFCLFFYKTH QDDFPLASLP LLGYTVSTPG EADSIHKEYV FKLQFKSHVY
FFRAESEYTF ERWMEVIKSA ASTAGRVSLL IPKGPGELNG N
//
