ID A0A3B1JPT6_ASTMX Unreviewed; 495 AA.
AC A0A3B1JPT6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Tubby-related protein 3-like {ECO:0000313|Ensembl:ENSAMXP00000043840.1};
GN Name=TULP3 {ECO:0000313|Ensembl:ENSAMXP00000043840.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000043840.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000043840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TUB family. {ECO:0000256|ARBA:ARBA00007129}.
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DR AlphaFoldDB; A0A3B1JPT6; -.
DR STRING; 7994.ENSAMXP00000043840; -.
DR Ensembl; ENSAMXT00000040700.1; ENSAMXP00000043840.1; ENSAMXG00000012132.2.
DR GeneTree; ENSGT00940000158155; -.
DR InParanoid; A0A3B1JPT6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000012132; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036333; P:hepatocyte homeostasis; IEA:Ensembl.
DR GO; GO:0061326; P:renal tubule development; IEA:Ensembl.
DR InterPro; IPR025659; Tubby-like_C.
DR InterPro; IPR000007; Tubby_C.
DR InterPro; IPR018066; Tubby_C_CS.
DR InterPro; IPR005398; Tubby_N.
DR PANTHER; PTHR16517:SF167; TUBBY-LIKE PROTEIN; 1.
DR PANTHER; PTHR16517; TUBBY-RELATED; 1.
DR Pfam; PF01167; Tub; 1.
DR Pfam; PF16322; Tub_N; 2.
DR PRINTS; PR01573; SUPERTUBBY.
DR PRINTS; PR01574; TUBBYPROTEIN.
DR SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
DR PROSITE; PS01200; TUB_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 48..102
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 104..220
FT /note="Tubby N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16322"
FT DOMAIN 238..447
FT /note="Tubby C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01167"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55317 MW; 3450EA938EC5404C CRC64;
MDSVKTSSQP VYSRWSYRPS SSASFTSTAN ASSLDDDSSS LRQQKLEKQR ALLEQKQRRK
RQEPLMVQPN PEARPRRSRP RRSEEQAPLV ESRLSITSDV ILDAGIDGPA AFLSSEAPDL
GTKIQVLSAS QPQKPSPPAA EEPERDGDTD TLLEPKTDIH TLLQRRGLSG SMNYDEVSDD
EDDDETEDRA GSLSPNTEST RPASASSTKS STECVTVGSP MAEGPSVEVE NLEEFVVRPA
PRGATIKCRI TRDKKGMDRG LYPTYFMHLE REDGKKLFLL AGRKRKKSKT SNYLISVDAT
DLSREGESFV GKLRSNMMGT KFTVYDNGTN PTKNPGTLLE ESNTRQELAA ICYETNVLGF
KGPRKMTVII PGMNMNFERV PVRPTNDQES LLSKWQNRAL DNLIELHNKA PVWNDDTQSY
VLNFHGRVTQ ASVKNFQIVH DNDREFIYTL SHGGWFSFIS SALSFSYLFL RFKDSLLCCL
SLFSGLHCDA VWSCG
//
