ID A0A3B1JR08_ASTMX Unreviewed; 625 AA.
AC A0A3B1JR08;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dynein cytoplasmic 1 intermediate chain 2 {ECO:0000313|Ensembl:ENSAMXP00000044832.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000044832.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000044832.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00011059}.
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DR AlphaFoldDB; A0A3B1JR08; -.
DR STRING; 7994.ENSAMXP00000044832; -.
DR Ensembl; ENSAMXT00000049457.1; ENSAMXP00000044832.1; ENSAMXG00000011514.2.
DR GeneTree; ENSGT00940000155442; -.
DR InParanoid; A0A3B1JR08; -.
DR OrthoDB; 654577at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000011514; Expressed in zone of skin and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF37; CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF11540; Dynein_IC2; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 70175 MW; D7CBC62E54D4DE51 CRC64;
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKEAEQL KEPVTLQDDS DLEKKRREAE
AMLQSIGITP DVPVVAPMSP TAKSVGTPSE AGSQDSGDGA TGPRTLHWDS DPSTLLLHSE
LGRGPVKLGM AKVTHVDFPP KEVVSYTKET QTPTMNEQKE DEEEEEELAP AEPVSEVEKE
TPVQKQEEEA PPHELTEEEK LQILHSEEFR DFFDHSTRII ERALSEHVDV FFDYSGRDLE
EKEGEMQAGA KLSLNRQFMD ERWSKHRVVT CLDWSPQYPE LLVASYNNNE EAPHEPDGVA
LVWNMKYKKT TPEYVFHCQS AVMSAAFVKF HPNLVVGGTY SGQIVLWDNR SNKRTPVQRT
PLSASAHTHP VYCVNVVGTQ NAHNLISIST DGKMCSWSLD MLSQPQDSME LVFKQSKAVA
VTSMSFPLGD VNNFVVGSED GSVYTACRHG SKAGISEMFE GHHGPITGIH CHTAAGPVDF
SHLFLTSSFD WTVKLWSTKN NKPLYSFEDN SDYVYDVMWS PVHPALFACV DGVGHLDLWN
LNNDTEVPTA SITVEGTPAL NRLRWAQSGR EIAVGDSDGQ ILIYEVGEQI AVPRNDEWTR
FVRTLAEINE NRDDAEELAA QRLPS
//
