ID A0A3B1JR73_ASTMX Unreviewed; 384 AA.
AC A0A3B1JR73;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=AIG1-type G domain-containing protein {ECO:0000259|PROSITE:PS51720};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000044345.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000044345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
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DR AlphaFoldDB; A0A3B1JR73; -.
DR STRING; 7994.ENSAMXP00000044345; -.
DR Ensembl; ENSAMXT00000030532.1; ENSAMXP00000044345.1; ENSAMXG00000040308.1.
DR GeneTree; ENSGT01100000263538; -.
DR InParanoid; A0A3B1JR73; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000040308; Expressed in mesonephros and 10 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01852; AIG1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903:SF195; GTPASE IMAP FAMILY MEMBER 3-LIKE-RELATED; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 32..231
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT REGION 50..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 321..355
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 384 AA; 43813 MW; 57ECCB859B8E4312 CRC64;
MQNLNDERMN VSMFCLFSAT EELSDPESPA PASELRLVLL GRTGCGKSAA GDSILGGEER
SQAGASTVRQ QSERRQGEVA GRKVTVVETP DWFSPELSLE ELRQDVEHCV RLSDPGPHAF
LLVLPVNQST GEERGMLEKM EEIFGERCWR NTMILFTGTD EVPEKIIERF VQSEDQDVQG
LVQKCGNRFH CLKTEKSGDD SQISELLEKI EKMVEGNEES FYSSEIYLEG YSAITEIEGL
DEEKNAIEEH EQDINKQTSE PESENKEDKD DKQIRKQEIR IEETHRQEIR EMTEGEAGLE
AECNIVQVNL LKVEASKLKM EEELSRRMEQ KDIEMEKLKQ RLSELEKAYH QEIKLNKTKN
LEKGARGPSQ KKTGMKKLLQ SELI
//
