ID A0A3B1JS50_ASTMX Unreviewed; 1013 AA.
AC A0A3B1JS50;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Liprin-beta-1 {ECO:0000313|Ensembl:ENSAMXP00000044169.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000044169.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000044169.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-beta subfamily.
CC {ECO:0000256|ARBA:ARBA00007547}.
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DR AlphaFoldDB; A0A3B1JS50; -.
DR STRING; 7994.ENSAMXP00000044169; -.
DR Ensembl; ENSAMXT00000043300.1; ENSAMXP00000044169.1; ENSAMXG00000020196.2.
DR GeneTree; ENSGT01050000244951; -.
DR InParanoid; A0A3B1JS50; -.
DR OrthoDB; 5396517at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000020196; Expressed in bone element and 14 other cell types or tissues.
DR CDD; cd09563; SAM_liprin-beta1_2_repeat1; 1.
DR CDD; cd09566; SAM_liprin-beta1_2_repeat2; 1.
DR CDD; cd09569; SAM_liprin-beta1_2_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037617; Liprin-beta_SAM_rpt_1.
DR InterPro; IPR037618; Liprin-beta_SAM_rpt_2.
DR InterPro; IPR037619; Liprin-beta_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF16; LIPRIN-BETA-1; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 653..717
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 730..788
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 277..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..161
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 321..355
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 362..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 114472 MW; 4B79E5088BF5AD0D CRC64;
MMSDASDMLA AALEQMDGII AGSKALDYSN GIFDCQSPTS PFMGGLRALH LLEDLRGVLE
LMDSEEREGL RCQIPDSTAD SLVEWLQGHL SNGHISVTGD IYQDRLNRLE SDKESLVLQV
SVLTDQVEAQ GEKIRDLDLC LEEHRDKLNA TEEMLQQELL LRSALETQKL ELISDISNLK
LKLTAVEKDR IDFDDRFRDS EGLILEINEL RYRISEMESE RLQYEKKLKS TKSLMAKLSS
LKIKMGQMQY EKQRKEHKIQ ALKEELVTLR RQLDGRDGEL RRLQDETGSR SPTPAGLESP
ERVYHTEETF KKRLKEKHLE VQRMKKAVES LMAANEEKDR KIEELRQSLM RYKKVQDMVM
SVQGRKDKLK EGESDESNSD SSLSMSAAIS VSMDTEKSML GCLEDGAEKS QAEPSFISTL
QVPSLTPSLQ TKHETEADLE QTHTQSDAGH QEPSQSQESP IDTSLEDVEV PKSGYQSNLS
SSPSEKRPLA VGPAESRAFD EFNKITTLPP KSPTVPRLSE DDSFGSKKAR SSFGRGFFKL
KGGKRTASAP NLAEAEREGT DHLDLAGMPQ RSGNSDSTHT LPTCPDGKKK SKGIKAFIGK
LRRSQSTTFN LDDNLSESEF KRGGVRATAG PRLGWSRDLH NSNSEVDAPF ARWSREQVCE
WMQEQGLGLY VNLARQWISS GHTLLQASQQ DLEKELGIKL PLHRKKLQLA LQALGSEEDD
NKGKLDYHWV TRWLDDIGLP QYKTHFDEGR VDGRMLHYMT VDDLLSLKVG SVLHHLSIKR
AIQVLRLNNY EPNCLRRRPS DENNISPAEV SQWTNHRVME WLRSVDLAEY APNLRGSGVH
GGLMVLEPRF NVETMALLLN IPPNKTLLRR HLATHFNLLI GSEAQQLKQD WLENPDYAVL
TATAKVKPRK LGFGTFGRKK KQEDSEEYVC PMDVEMPKGR SFQKGYRGME LQIYEDDLDR
LEQMEDSEGT VRQIGAFSEG INNLTSMLKD DEFFKELSTS SPNPSVTDDD SNV
//
