ID A0A3B1JSE4_ASTMX Unreviewed; 608 AA.
AC A0A3B1JSE4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rap1 GTPase-GDP dissociation stimulator 1 {ECO:0000313|Ensembl:ENSAMXP00000044661.1};
GN Name=RAP1GDS1 {ECO:0000313|Ensembl:ENSAMXP00000044661.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000044661.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000044661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
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DR RefSeq; XP_007239850.1; XM_007239788.2.
DR AlphaFoldDB; A0A3B1JSE4; -.
DR STRING; 7994.ENSAMXP00000044661; -.
DR Ensembl; ENSAMXT00000036705.1; ENSAMXP00000044661.1; ENSAMXG00000013835.2.
DR GeneID; 103037573; -.
DR KEGG; amex:103037573; -.
DR CTD; 5910; -.
DR GeneTree; ENSGT00390000014293; -.
DR InParanoid; A0A3B1JSE4; -.
DR OMA; IAWLINN; -.
DR OrthoDB; 2951120at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013835; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040144; RAP1GDS1.
DR PANTHER; PTHR10957; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR PANTHER; PTHR10957:SF2; RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50176; ARM_REPEAT; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 90..132
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 358..390
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 608 AA; 65949 MW; F0D1B0DBCBC3033F CRC64;
MADNLSEALK TLKLSSADSA TDSVESCLDC LLKALAHNNV EASEKIQQMG VLPMMPSLLA
TQNSCTPKVA NIIAEVAKNE FMRSPCVEAG LIPPLVQLLN CKDQEVLLQT GRALGNICYD
SHEGRSAVDA AGGAQIVAEH IKALAQNTDP STGKLLTVFC GMLMNYSNDN DTLQAQLISM
GVIPTLVKLL GVHAQNTALT EMCLIAFGNL AELESSKEQF ASTNIAEVLV RLFRKQAEHD
KKEMIFEVLA PLAENDVIKL QLVEAGLVEC LLDVVGQTVD SEREEDVAQL KTASDLMVLL
LLGDESMQKL FEGGKGSVFQ RVLSWVPSNN HQLQLAGALA IANFARNDGN CIHMVDTGIV
QRLLELLDRH VEEGNVTVQH AALSALRNLA IPVVNKAKML SAGVADVVLK FLQSEMPPVQ
FKLLGTLRML IDTQADAADQ LGTNRKLVER LVEWCEAKDH AGVMGESNRL LSALIRHSKS
KEVVRTVIQC GGVKHLVTMA TSEHMIMQNE ALVALGLIAA LDLDSAEKDF VGATLVQVLH
KLLTEEKSAP EIKYNSMILI CSVMGSEPLH KEVQSLAFID VVSKLRSHEN KTVAHQASLT
EQRLTAQS
//
