ID A0A3B1JSE5_ASTMX Unreviewed; 145 AA.
AC A0A3B1JSE5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Receptor activity-modifying protein 1 {ECO:0000256|ARBA:ARBA00041071};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000044269.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000044269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC {ECO:0000256|ARBA:ARBA00037503}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1.
CC {ECO:0000256|ARBA:ARBA00038839}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the RAMP family.
CC {ECO:0000256|ARBA:ARBA00007087}.
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DR RefSeq; XP_007260636.1; XM_007260574.2.
DR AlphaFoldDB; A0A3B1JSE5; -.
DR STRING; 7994.ENSAMXP00000044269; -.
DR Ensembl; ENSAMXT00000041964.1; ENSAMXP00000044269.1; ENSAMXG00000037528.1.
DR GeneID; 103028618; -.
DR KEGG; amex:103028618; -.
DR CTD; 10267; -.
DR GeneTree; ENSGT00940000159224; -.
DR InParanoid; A0A3B1JSE5; -.
DR OMA; CYWPNRM; -.
DR OrthoDB; 4199890at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000037528; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; Receptor activity modifying family; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP; 1.
DR PANTHER; PTHR14076:SF3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 1; 1.
DR Pfam; PF04901; RAMP; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..145
FT /note="Receptor activity-modifying protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017474382"
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 145 AA; 16431 MW; 35AF0E48541E27A4 CRC64;
MGLSSAPVSS LCLILATLCA AALACSSHYE YAIEEFCLAK FKLDMEALDQ GHWCSWEDTV
ESYGELTNCT FLVALKMNCF WPNRLVDEFF IRVHRHYFQD CSLSGRLLHD PPNRILGPFI
IVPILVTLLM TALVVWRSKR SEGIV
//
