ID A0A3B1JTT2_ASTMX Unreviewed; 1276 AA.
AC A0A3B1JTT2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000045146.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000045146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JTT2; -.
DR Ensembl; ENSAMXT00000053112.1; ENSAMXP00000045146.1; ENSAMXG00000006770.2.
DR GeneTree; ENSGT01100000263535; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006770; Expressed in bone element and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR46484:SF5; MYELIN-ASSOCIATED GLYCOPROTEIN-LIKE-RELATED; 1.
DR PANTHER; PTHR46484; SI:CH211-171H4.5-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SMART; SM00409; IG; 8.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1276
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017274774"
FT TRANSMEM 1210..1235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 468..556
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 564..653
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 880..966
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1107..1200
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 1276 AA; 143212 MW; 0D34D00934BBB9AD CRC64;
MAGLFLLHVI FQGILFSGTS AWSVWMPRHI RGLRGSCLVI PCSYDYSAYP PWNPYRVVWY
QYVSRGYPVV YDSWDPGSVI QKFRGKTYLY RDPHTRDCSL LIKDLNLAHH GERIYAWVDP
ENVGWRTYAF YDVTSEIHIE TSAQTPSLQI TGGANIGDTV SVQCSTYHTC PYNKPTISLS
GINNKVGTSD KVENRDIGDG KYRITLTRRG VVQAESQGVT CTVTHPGGLS ASAFKEHTAK
CAIYTASISP DSNTEFLEGV EKAIICSITY MCPQNRPYIT WNGGQLPGSM SEERIGTKIV
AKSTLKFTAK ASDNGKDITC RTEIKGNVQR VKITLKIKRS MFSRDWSFSM PNTIRGVQGS
CVVIPCSFSF KNSQPSHVNV KWYKFSASEY PLVYDQSASN IISEFRGKTS LYGSNMGNCS
LKIQPLDSQH NQQRLYPWMD AQSITSYHRE NYLAITLGLE VTNSIEKPQV DIIGIPKVGE
KLTLSCSVIH TCPPTPPELS LSISRGTGHL THTPQNEGKW KTVKEITWDV QEDDTSVSCT
VSYSGTQTAM TEVRLSPSCT FQKPTISPTQ DEVMEGIEKT FTCTVQHTCQ KQKPSLTWNF
ENMPASVKTE KMSSTWTTVS TLKLKAARDD HDKTLTCTAQ SGGEQSSDSV VLKVKRGMSS
LDWTYSMPSK IKGLRGSCLI IPCSFEFKST MPSNTMVKWY EYSSTTFPLV YAQDGQNVIG
KFWGKTELNG SASEGKCSLK IYPLLMEHNR ERLYPWMDQK PVETFHSVNH RDSCVELEVT
EQAEKPKLSI TGVPRVGEQI TVSCSIYHTC PWSPPTLKMG AAQQTDRTEH VPKQDGFWET
TKHHTFKIKE DDQSITCKAT FSGEQTSEAK IDLNAQCIHQ DIMIEPELAD VTEGVATNFT
CNVLHSCMRQ IPTITWNYED MPETVKTKEN RVSGYITSSN VQFIASMEDH GKKLVCTAKF
PEEEITASVV FQVQKYVPKI VDPFENDTVH VFEADVVPRI SALTRSCVVI PCTFDIGSEP
VTRLRGLWYD TNGDYVYHTG QTNVMDNFKG RTELLGEPDE KNCTLEIDDV KAHDNGPFCF
HAEKGNDKYR FNHSCVFIVM KASPDKPVIS GLPEEMEPGK KFSLSCSVTH TCPSHPPTIK
WSIKTAKEVV SHMEGSAGQW KTTSTVTFIP TGYENEDDLL CSASFWRGKK QETAIYLPIT
RYEGLKMETI GYYILAPFFS ILLLFILFTV GVVLYRRRVG KEPSDGDTLD KRRSVWARFS
RRADGTASWL ASAEIK
//
