ID A0A3B1JU20_ASTMX Unreviewed; 318 AA.
AC A0A3B1JU20;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ras association domain family member 5 {ECO:0000313|Ensembl:ENSAMXP00000045345.1};
GN Name=RASSF5 {ECO:0000313|Ensembl:ENSAMXP00000045345.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000045345.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000045345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B1JU20; -.
DR Ensembl; ENSAMXT00000039959.1; ENSAMXP00000045345.1; ENSAMXG00000036315.1.
DR GeneTree; ENSGT00940000159288; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036315; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21892; SARAH_RASSF5; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF9; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 180..264
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 266..313
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT REGION 98..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 285..312
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 318 AA; 35882 MW; 3D4BD2B11C72A777 CRC64;
MRAAHDDAAA AGACFTQVSR RIGRLFRRLP KSRSWSEGLR LLRRSSSSGA LVLADCSYTC
HLECEGLVQL DCNQKDGQTE ETSTSSPCRP YSMPLAVKKA TKEEEEENPK SLSEEEVKSK
IEEYNSKVSE NGMNLAEDGT YTGFIKVHLK LRRPVTILSP DGKAPGCSPA ADVSDRRTSF
YMPSDTVKQL HISSTTTVNE VIQGLLKKYT VQDNPRKFAL YRRTHRDGQD LIQKLAGTEH
PLFLRLLAGP DLENLSFVLK ENETGEVEWH AFSVPELQNF LTILEKEERE RVKQVELRYT
AYKNKLMEAL QEVQNKPG
//
