ID A0A3B1JUA8_ASTMX Unreviewed; 886 AA.
AC A0A3B1JUA8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Pleckstrin and Sec7 domain containing 2 {ECO:0000313|Ensembl:ENSAMXP00000045848.1};
GN Name=PSD2 {ECO:0000313|Ensembl:ENSAMXP00000045848.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000045848.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000045848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A3B1JUA8; -.
DR STRING; 7994.ENSAMXP00000045848; -.
DR Ensembl; ENSAMXT00000054805.1; ENSAMXP00000045848.1; ENSAMXG00000036801.1.
DR GeneTree; ENSGT00940000159674; -.
DR InParanoid; A0A3B1JUA8; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036801; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR GO; GO:0061053; P:somite development; IEA:Ensembl.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF329; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 375..577
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 627..740
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 768..795
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 56..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 98036 MW; 11B8C336A07BF059 CRC64;
MSQEGQGDPL HADTPPPEML AQAQEKAEIP ETGDVEQVNM ENDVKGVNGS ECECEAEEQV
NGDDGEMEAD SEDARPEEEH IGDVLANGDV EGERTEEEQI AEDSKKNGDS ESCCLQAESD
HSIGDSANVP SSECGGLGVP PPPSDQPSED SAEPQDPVRV QNGTGEDSEG QEEDEGCDEE
PARGNVDKFS STFELSVEET DAEVEEEEEV QNQDSFSSAF ERIVEQASGS VALEDEEEDA
GEEEQDRTKE TQDGFSSTFE RIVESELLRG GTCYSSLDSL DVLSLTDETD SCVSFEAPLT
PLIQQRALVG PEPPELELET VQEGAETQEG EGEGDNGMDE AGSGSPLRTS IPGSRSENVL
SQPAQWSIPN GFHNDLPVNR ERSGILPSSV SDANLTDGLC DSELGSLETL ERGSTDTLAN
GCRADADASK RLAKRLFYLE GFKRCDVARH LGKNNDFSQM VASEYLSFFD FTGLSLDRAL
RNFLKAFPLM GETQERERVL VHFSKRFCHC NPEALTSEDG AHTLTCALML LNTDLHGHNI
GKKMSCQQFI SNLDGLNDGK DFPKELLKVL YNSIKNEKLE WAIEEEELRK SLSELVEDQC
EAGGKRVVRV TDGSNPFIAI PLLLNAATYK HGILSRKSHA DMDGKRTPRG RRGWKKFYAV
LKGMILYLQK DEYKPDKDLS EVDLKNAVRV HHALATRAND YSKRPNVLKL KTSDWRVFLF
QAPSEEEMMS WIFRINLVAA LFSAPAFPAA IGSMKKFCRP LLPSSTTRLK EEEQLKCHES
KLKQISLEVE EHKKSPPELT PKSKETEEYR IKEHYLTYEK SRYETYVNLL QAKLRVGSDD
LDKIEASLFS GDGRDCHLRK TQSSPSISQG PGLNGRAAHK NPDNHS
//
