ID A0A3B1JWV6_ASTMX Unreviewed; 1338 AA.
AC A0A3B1JWV6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000046758.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000046758.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR Ensembl; ENSAMXT00000054230.1; ENSAMXP00000046758.1; ENSAMXG00000038338.1.
DR GeneTree; ENSGT01100000263500; -.
DR InParanoid; A0A3B1JWV6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000038338; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 323..502
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 913..1071
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 1296..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1338 AA; 148256 MW; FC87C7B232EAE53B CRC64;
MVSTVTESFF LQQFEPWGHD RLQSCHWLQL RAANGLDIPY IGYLELEVLL CNKVMPRCGI
LVVKDPPGAS STVPGVLGMN IISRCYHELF GLHGSSFFQL PSVAHAPSPV VAALQQCHQS
AAQVPRDPMG TVKVRGTRAV RIPGGVMKLV ASTCAELPLG RSAFFEPLEV GLPAGLLASP
CLVQVNRGTV YVPIVNVGIA EVFLHPHTHL GSLSMVQVIS LPTGITEVRS TTATVSSQVV
ASSAPNGVEA VDLSALTDQE QGVVRSLLQK YNSVFSAHDG DLGCTNLIEH EIPLLDNIPV
RQRHRRIPPS DYELVKAHID QLLEAQVVRE SSSPYASPIV LVKKKDGSLR MCVDYRLLNS
KTRKDAFPLP RIEESLDALS GARWFSTLDL ASGYNQVPVA EQDKPKTAFC TPFGLFEWNR
MPFGLCNAPS TFQRLMQRMF GDQQYQSLLL YLDDIIVFSS SVSQHLQRLE VVLGRLQKEG
LKAKLSKCVF FKQEVGYLGH VISNKGVSTD PAKIEAVAQW QRPRTVSELR SFLGFASYYR
RFVEGFAQLA GPLHKLVAAL VGSKTKKGSG QALGMAWTAQ CEQSFEALKA RLVSAPVLAY
ADFSLPFILE IDASYSGLGA VLSQEHDGAV RPVAYASRGL RPPERNMDNY SSMKLEFLAL
KWAMTEKFRE YLLGHKCVVY TDNNPLSYLQ SAKLGAMEHR WAAQLAAFDF EIKYRSGRSN
KNADALSRQY QLGPSVTEYV PGTPVPELVQ QASPVVSATQ ALVSVLPGSS PVDIHSLQDA
DPLLREVLVF WRKQVQPTSA EKRQVSRPAM ALLRQWDRLV ERDGVLYRRV FRPDGGEESF
QLLLPAVLKP EVLKQLHQDH GHQGIERTSE LVRQRCYWPG MFADIKQWCR ECERCQVAKD
AGPVPHSFMG HLLASRPNEI VAIDFTVLEP SRNGLENVLV MTDVFSKYTI AVPTRDQRAS
TVAQVLLREW FYKFGVPGRI HSDQGRSFES ALIQQFCHLY GVERSRTTPY HPAGNGQCER
FNRTLHNLLR TLPTSRKQDW ASNLPQVIFC YNTTPHQGTG ESPYYLMFGQ EPRLPVDFLL
GQVQEPVPGE VQDWVIEHQA RLRLAFEGAR DRLLVAAGRR KERHDQRVRE VPLQEGQLVY
LRDHSARGRH KIQDVWSSVV HQVLRTPPGE GAVYTVAPVS DLGKIKHVHR NMLKAQVQAQ
GPLLPPRDSP PPVPVAPVDT SSDCDLWLLV SETISPEVAV PSGSGTTVPP TVQPAQEGIL
DATTVQGGRQ PSDSSLFLTG QPCSGLSSVR RTARATAGQH SNIHRLPRSA GSVDNGVDEP
SGLVNTQSAL FRPWCWPP
//
