ID A0A3B1JXD6_ASTMX Unreviewed; 732 AA.
AC A0A3B1JXD6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=EMAP like 1 {ECO:0000313|Ensembl:ENSAMXP00000046495.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000046495.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000046495.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR AlphaFoldDB; A0A3B1JXD6; -.
DR Ensembl; ENSAMXT00000032900.1; ENSAMXP00000046495.1; ENSAMXG00000013344.2.
DR GeneTree; ENSGT00940000153887; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013344; Expressed in camera-type eye and 12 other cell types or tissues.
DR CDD; cd21947; TD_EMAP1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF22; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 106..177
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 456..488
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 516..599
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 539..580
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 585..616
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 697..732
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT COILED 33..60
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 732 AA; 81553 MW; 98A9FD806D2D61A5 CRC64;
MLLNFILRDK KSIYICVCVY LYFLDDSASA ASSMEVTDRI ASLEQRVQMQ EDEIQLLKSA
LADVVRRLNI SEEQQALLNR KGPTKVTLKS VLLCKSVALV EEGYVKMYLK GRPITMYLPK
DLVDSYCLEA KAELPVKKLK LEWVYGYRGR DCRSNLYLLP TGETLYFIAS VVVLYNVDEQ
LQRHYTGHTD DIKCLAVHPD KITIATGQVA GTSSDGKQLA PHVRVWDSVS LNTLHVLGSG
FFDRALVCLS FSKSNGGSWL CVVDDSNDHV LSVWDWQREE RLAEVKCSNE SVFATDFHPT
DANTIVTCGK SHLYFWSLEK NSLVKKQGLF EKQEKPKFVL CVTFSENGDA ITGDSSGNIL
VWGKGSNRIS LAVQAAHESS VLALCMLRNG TLLSGGKDRR ITAWDGNYQK IQTVEIPEVY
GPIRTVAEGR GETVLIGTTK NYVLQGSLDG EFTPITQGHT DELWGLAVHP LKHQFLTCGH
DKLVCLWDCD QHQPLWTKTM EDAAQSAGFH PSGATVAIGT QTGRWLVLDT ETKDLVTMHT
DGNEQISVMS FSPDGNFLAI GSHDNYIYIY AVSENGRKYS RVGKCSGHSS FITHLDWSVD
SQYLVSNSGD YEILYWIPSV CKQVVSVETT RDIPWSSFTC TLSFHVFGLW PDGSDGTDVN
AVCRSNETRL LATGDDFGKV HLFSFPCSQS RAPSHMYGGH SSHVTNVHFL FNDSHLVSTG
GKDMSVMQWR VV
//
