ID   A0A3B1JXE6_ASTMX        Unreviewed;       818 AA.
AC   A0A3B1JXE6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Myotubularin related protein 11 {ECO:0000313|Ensembl:ENSAMXP00000046505.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000046505.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000046505.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A3B1JXE6; -.
DR   STRING; 7994.ENSAMXP00000046505; -.
DR   Ensembl; ENSAMXT00000048989.1; ENSAMXP00000046505.1; ENSAMXG00000024622.2.
DR   GeneTree; ENSGT00940000160276; -.
DR   InParanoid; A0A3B1JXE6; -.
DR   OrthoDB; 5474662at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000024622; Expressed in liver and 14 other cell types or tissues.
DR   CDD; cd15790; PH-GRAM_MTMR11; 1.
DR   CDD; cd14595; PTP-MTMR11; 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          203..662
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          698..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  91771 MW;  6AA39D3AECB1541A CRC64;
     MLTGSKTTFK VRQMPDIKER IMNQSGLHAR GRDMFGLCCL PGECVLQRAV LVRKKLSPKE
     GGGWLSGTLF CTHFRVAFVP QDSPRPDDNA DPVLLGDHDV ALASIEKVVA VGPLRTKLVT
     PSSSLKFTPE ELILYCRDLR VLCFLFDRLT PDTQAVEITY TIAKTYHPLK PGTILSFQNA
     ALGSIEMKQF LSNRRRDSGM NWFESSGDWE QELERTGATG WRVSSVNDRF EMSTSLSRFN
     VVPQKVLDTE LKKTFAHFNE GRIPRWVWRH PHGSDLLRMA SFQNNIYHEK DDIRNLELIL
     FGGQSQCIVV DLGDEMPSPA DLQLAHTRLR TLCLGDISSS VSVPDDKWLS SLEGTHWLDY
     IRCCLRKAAE VACLLRRGHL TVVLQEPEDR DMNCVVSSLV QVMCDQHCRT VAGFQALVQK
     EWVVAGHRFL SRINYHRDSD KEEAPIFLLF LDCVWQLWAQ FPARFQLTED FLLALHDSLH
     LPLFSTFLAN CQRERCRRSQ NLPQSYTPVN GLRELPRGSV EEPVDPPYPP VWDWALQYST
     QRRALFTQPV CQPSTPAPVL NGNFNTNLGP NWISDGVPGS VFLLSRSLFS CPSNLLPWRS
     GGGSVSYRKS HRRAPSSESL PALERLIKAC GQPDPLQDIH DPHQPLIPLL LGPCVRIWRN
     CYLRGALHAQ AFTHPMSSNA RHPVERLASE VEHLRERLAQ ASVGRPPNRK RHEHRRLDSN
     LNQNTNNGTF LFSSSSSSSS SSSSSSSSSS SSSSRASQQE SPSRFSARPP AAARYRDGGG
     KHTFLFGHQG EPQSSQRYAP CPGAKLPKNS GPSGAKTH
//