ID   A0A3B1JZG0_ASTMX        Unreviewed;       652 AA.
AC   A0A3B1JZG0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Neurexin-2 {ECO:0000313|Ensembl:ENSAMXP00000047111.1};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000047111.1, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000047111.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   AlphaFoldDB; A0A3B1JZG0; -.
DR   Ensembl; ENSAMXT00000044091.1; ENSAMXP00000047111.1; ENSAMXG00000039087.1.
DR   GeneTree; ENSGT00940000163749; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000039087; Expressed in brain and 8 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003585; Neurexin-like.
DR   PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR   PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        577..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          110..280
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   REGION          431..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..557
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..652
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  70546 MW;  EDB60F536B78CC7D CRC64;
     MSSCFCRVRR QGMEVPPPSP SALGAVVLVS GLVLTPQSPP STPHRAFWAS LWRLVLSLSL
     LAFPGPAVSA RVSSSLSTTH HVHHFHNKHG TVPIAINRMP FLTRGGHAGT TYIFGRGGAL
     ITYTWPPNDR PSTRADRLAV GFSTQLKEAV LVRVESAKGL GDYLELHIER GKIGVIFNVG
     TDDIAIEESG VVVSDGKYHV VRFTRSGGNA TLQVDNQPVI ERFPSGRQLT IFNSQAFIKI
     GGGEKGRNFQ GQISGLYYNG LQVLKLAAEG DPNVQVQGNL RLVGDVPSVL TTDTTSTTPL
     ADMSTTIMET TTTMATTTTR KQRSPTMRDS VTQNTDDLLV ASAECPSDDE DLEECEPGGG
     ELVLPIITVD SLDPPSVATR YPVIPPPPTY RPFLTLLDTT KESLSLPNGR APCPLDQEDC
     EEAMEVSAYG SGEMTESDDE DYYKNSPLVT DRTVIPPPPA AENTRGDRHF SRHPDSHRPP
     LPSTPTAHPE QLVPRVKPGI NSGNNIPAGK MNNRDQVLLP PAQPSGDPEH GGRHRHIPGI
     TYPPNFPHIP TTDPSSPDRG PPGAVEVIRE SSSTTGMVVG IVAAAALCIL ILLYAMYKYR
     NRDEGSYQVD QTRNYISNSA TQSNGALVKE KQSGTTKTGT KSKKNKDKEY YV
//