ID A0A3B1JZT6_ASTMX Unreviewed; 2356 AA.
AC A0A3B1JZT6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000047922.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000047922.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000052834.1; ENSAMXP00000047922.1; ENSAMXG00000008874.2.
DR GeneTree; ENSGT00940000155126; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000008874; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd00061; FN1; 11.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 13.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 13.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF49265; Fibronectin type III; 10.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 4.
DR PROSITE; PS51091; FN1_2; 11.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 14.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..2356
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017201791"
FT DOMAIN 51..90
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 95..138
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 139..182
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 184..228
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 229..273
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 357..405
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 417..465
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 470..513
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 518..560
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 561..604
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 608..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 792..881
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 888..979
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 980..1067
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1069..1155
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1156..1246
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1249..1342
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1343..1430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1431..1520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1527..1619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1624..1715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1726..1815
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1818..1910
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2084..2177
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2184..2228
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2229..2271
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2273..2313
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 697..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1505..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1968..2047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2027..2041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 362..388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 376..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 422..448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 436..463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2356 AA; 258370 MW; A47FF45C04327767 CRC64;
MLRGSVAGLL LLCAGSAVLG GPQAGRGEEQ QQQVALDTAF LEATQYSGLQ EGCTENSRFY
RANEQWERPY MGSTLLCTCR GSAGVTCESK PAMEETCYDK VNMRSYRVGE TYERPKDGMI
WDCTCIGSGK GKISCTIANR CHEGGRSYRI GEKWTRPHDT GDYMLECVCL GNGKGEWTCK
PVAERCYDSS VGSSYVVGQT WEKPYQGWMI VDCTCLGEGN GRITCTSRNR CNDQDTRKSY
RIGETWSKVD TNGHRLQCLC TGNGRGEWKC ERHSSTHTAL GMELVAQVRP VTHQVDVVNQ
LVEEEGSCRV ASEVIYSNGM SWVQTQGSQQ RICTCVNGGI GCEDWDGQSS QVYGGNSNGQ
PCVFPFVFEG KTHYSCISEG RTDGQLWCST TSDYDSDGQY SFCTQRNLMV TTRGGNSNGA
MCKFPFIYNG RNYTDCTADG RRDGMKWCGT TTNYDDEQRF GFCPMAAHEE ICTANDAMYR
LGDQWDKRHD TMGHLMRCTC LGNGRGEWSC IAYSQLRDQC IVDGHTYEVN QNFDKRHTEG
YMMNCTCFGQ GRGRWKCDAI DQCQEPESKA FYQIGEAWDK VIQGIRYRCY CHGNGIGEQA
CEPLLSSVPV RVIITETGNK PNSHPIQWNP PSSAHITEYI LKWRVKNTRT PWKQAVIPGH
INFYTISGLK SGLTYEGQLV SILHSGRRET TRFDFTTSHG SLIPTEGITT PPPPVLDTSE
SVTEITSSSF VISWVSASDT ISGFRVEYEL SEEGAQPSVI DLPRTATSVF EVQPGGDTNI
ILHTTQTTAP DAPTDHRVTG VEETSIVISW TRPQAPITGY RVVYTPSEEG SSTELILPES
VTTVTLVDLQ PGSQYNVSIY AVEDNQESVP VVLQVNTAGE PQPEETPAPT DLQFYEVTDT
KITITWNGPP SEVSGYRVTF EPVTPDDRPQ KALQLPVTPN AYAEITHLQP GTLYRFHIYA
VHGGSESQPL VGDRRTKPDS PSELRFSDIT ENSALVMWSA PQAQVTGYSL FITTDGSAHK
HLRIPSHETQ YTVSNLQPDT DYIVVLHSEQ GSTLSEGIRG TFTTTPLLGR APPFSTDVTD
TSIIISWSPV PRISYKLSVR PSQGGEAPRE VTSGSGSIYI SGLTPGVEYT YSVQPIINGR
KQGNPITRTA VTPLSPPTDL NVASNPDTGE LNVRWREAQI PDISGYRVTC APTNGQRGNS
LEEFIRAGQT SGTLENLSPG VEYNVSVYTV KNHIESEPIS TTVTQAIPSP TNLNFGEVGP
DSMRVSWTRP SVQPTEISRF VIRYHPSNND DDSHEVNVGG ATSTFLLQNL LPVTEYLVSV
VSVYGERESS PISGRQTTTL DSPTGLDFSE VFTNSFTVHW IAPRAIITGY RLRYQPTTGG
RYKDERLPPT RTYYTLTSLT PETEYSVQIY ALSGSKESQP LTGTQATISD APTDLEVTSS
TPNSITISWE APSIPVRYYR ITHGETGHGP PKEFTVRGTE STATIPGLRP GTDYTITVYA
VTGRGDSPAS STPTIITHRT GTDRAPSPSD LDVTNIEDNS MTVRWSPAKG PITGYRVTGA
PKEGVGPTFT KVVGPDQTQL KVTGLQPTVE YVLSVYAIGP DGESPLGVER GTTSEVHIPT
AVDRPTDLSF RDVDSTSLRV TWTPPRGPVT SYRVLYSSPE EGEREWRPAP RGQDDSVLLR
GLRPGTQYTV KVLPINGATP GTMLRGAQAT ITESVSRILL FIAVPAPTNI QFGEVGPSSF
IVLWTPPSAR LSGYRVLITP KNNIAAPKQM NVAPDSTQVT VPGLLVSTLY EVHVYALKDS
LSSRPLIGEV TTAEDISPPR RVRISDVKDT SITLVWRTKM GEPMTGFLIE ATPTSGSYPT
VRKVIPEDAR AVTITGLQPG VSYLISLYTL NGDSRSSPFT LTVTTGTPLN VLQTATNLTK
CLQSVFPTRC STYCWPLYQK HLLTLISGLR PSTEYIIKIV ALQNAQRSPP LVGKARTQDS
SSLLPTPPRR GSGHDRLDVP EVDIDDNRVH GAGPTAQPGQ PDGGQIVEYT EYNNQPGTPT
HGGYQPVRPR PSLVYVPQAG PDGARVPVVV QVSERPGHGL PFHFPGNKSG MPQEAQTQTT
VTWQPYQQSS AYLVSCHPIT HRDEKMFQMR LPSTSTSATL IGLTSGASYN VIVEALKGAL
KHKILEETIT AGNTVQEGSS PSSDACYDTF TATYHNVGEE WERMSETGFK LWCRCLGLGS
GHFRCDSSKW CHDSGNNYRI GEKWDRQAEN GHMMSCTCLG NGKGEFKCEP HASTCYDDGK
MYQVGNQWQK EYLGAICTCT CYGGQQGWRC ENCRRPGAEI DAGLLKPVSS DNIQCPIECL
RPDLLADAVA NPNTRE
//