ID A0A3B1K034_ASTMX Unreviewed; 699 AA.
AC A0A3B1K034;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000048017.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000048017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000042943.1; ENSAMXP00000051275.1; ENSAMXG00000037170.1.
DR Ensembl; ENSAMXT00000056182.1; ENSAMXP00000048017.1; ENSAMXG00000037170.1.
DR GeneTree; ENSGT01100000263547; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000037170; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 195..329
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 80391 MW; FF17982FCD7AEA93 CRC64;
MKSDGSLVNP PDLSSEPVTS DPKDKKISFS REKVEHIFKE LQQKFISLVK NELNTFKKLL
SPDYPACSER EEEDEDDQRE GVLKITLHIL RKMKEKDLAN TLESKLAPAC RLKLKSTLWK
KVQRINEGIT NPETSVLLNQ IYTELYITQG GGGEINQEHE VRQIEDASRK RTTQEIPIKC
NDIFKPLPEQ NRPIRTVLTK GVAGIGKTFS VQKFILDWAE GKVNQDVLFI FPLPFRELNL
MKEKKLSLVN LLQRFFPETQ DLKPRHYKSY KIMFIFDGLD ECRLPLDFQN NENLVDIEEQ
TSVDVLLTNL IKKNLLPSAL LWITTRPAAA NQIPPDCIDQ VTEVRGFSDP QKEEYFRKRI
RDQSLAERII THMKSSRSLY IMCHIPVFCW ISATVLERML GEAEGGEIPK TLTQMFTHFL
IFQIKHRSQK YHHNSEDDLK QTRKIILALG KLAFQQLEKG NLIFYEEDLK ECSIDVKEVF
VYSGVCTQIF RQESELHLGK VFSFVHLSVQ EFLAALYAFL SFISNNRNVL PGVLDFSKKG
TMSDFLKRAV DEALKSKNGH LDLFLRFLLG LSLESNQTLL RGLLIQTGSI SHSKEEVVKH
IKQKIKENLS PEKTISLFHC LNELNDHSLV QEVQHYLNRG GGSSHLSIVT LSPAQWSAVA
FVMLNSEEEL DEFDLSKFQK SEECLLRLLP VVKTSRKIV
//
