ID A0A3B1K154_ASTMX Unreviewed; 826 AA.
AC A0A3B1K154;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein Jade-1 {ECO:0000256|ARBA:ARBA00040212};
DE AltName: Full=Jade family PHD finger protein 1 {ECO:0000256|ARBA:ARBA00041998};
DE AltName: Full=PHD finger protein 17 {ECO:0000256|ARBA:ARBA00042970};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000048228.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000048228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
CC -!- SIMILARITY: Belongs to the JADE family.
CC {ECO:0000256|ARBA:ARBA00038371}.
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DR AlphaFoldDB; A0A3B1K154; -.
DR Ensembl; ENSAMXT00000034269.1; ENSAMXP00000048228.1; ENSAMXG00000017786.2.
DR GeneTree; ENSGT00940000158247; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000017786; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15671; ePHD_JADE; 1.
DR CDD; cd15679; PHD_JADE1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039546; Jade-1_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF79; PROTEIN JADE-1; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 9..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 225..275
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 277..391
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 598..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 93605 MW; 182FCBFA7F43E41D CRC64;
MSNPVFKSIV ITFVLINLYT STLVAIICWV EWYSLSLALS FCCLGNCTSW SQMSNSHRRR
EGKRPSEVFR TDLITAMKLH DSYQLNPEDY YVLSDPWRQE WEKGVQVPVS PHSIPKPTVR
VVADKSSALL FTRPKKLIRT WGAEASALGY VAIGTLSEGM CRYDLNEEDV AWLELANKEF
SAMGMQLLDE NTMERVMEEF ERHCYDNMSH AMETEEGLGI EYDEDVVCDV CQSPDGEDGN
EMVFCDKCNI CVHQACYGIL KVPEGSWLCR TCALGISPKC QLCPKKGGAM KPTRSGSKWV
HVSCALWIPE VSIGNPEKME PITSVSQIPN NRWALICCLC KEKTGACIQC SAKSCRVAFH
VTCGLQFGLK MNTILTDDDE VKFKSFCPTH SGMDWTDSYA GANEDGGIRV RGVNAADPCG
AHLSERKLRV QQLEDEFYRF VAPDEVAKHL RLPAETVDFL FQYWKLKRKA SFNQPLVTPK
REEEESLARR EQEVLLRRLR LFTHLRQDLE RVRNLTYMVT RREKIKRSVC RVQEQIFHHH
VRLLEQGRLS GVSSTRRLEE AMFYFRAASM SLQPLRGHAA QNSAICHSQR KNLLRHGASR
RAHCEGEEPA KVSSTERSEA TDAAAAVYSG SRGRRGEYSR NETEQPLEEQ RRKRRNMAWE
PLPVREKHKS GGTEAEMEVD SSESEAKSSC PVTVQSRYNG SLRRTSSSQG KLLANGTSAQ
HIKNWGSFRI PKRSDRTSGG GHEELEGQDF THSPHVSSLD ESPTPSTSPP IRTRLRMGAD
SRSFAQETEH SQSEQKKRCH AQRLRSHDPI TQRYGSEVLR RGVLAS
//
