ID A0A3B1K339_ASTMX Unreviewed; 285 AA.
AC A0A3B1K339;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Synaptoporin {ECO:0000313|Ensembl:ENSAMXP00000048386.1};
GN Name=SYNPR {ECO:0000313|Ensembl:ENSAMXP00000048386.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000048386.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000048386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00006476}.
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DR RefSeq; XP_015458049.1; XM_015602563.1.
DR AlphaFoldDB; A0A3B1K339; -.
DR STRING; 7994.ENSAMXP00000048386; -.
DR Ensembl; ENSAMXT00000058081.1; ENSAMXP00000048386.1; ENSAMXG00000033187.1.
DR GeneID; 103035011; -.
DR CTD; 558290; -.
DR GeneTree; ENSGT01030000234637; -.
DR InParanoid; A0A3B1K339; -.
DR OrthoDB; 2881347at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000033187; Expressed in camera-type eye and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008021; C:synaptic vesicle; IEA:InterPro.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR001285; Synaptophysin/porin.
DR PANTHER; PTHR10306; SYNAPTOPHYSIN; 1.
DR PANTHER; PTHR10306:SF16; SYNAPTOPORIN; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR00220; SYNAPTOPHYSN.
DR PROSITE; PS51225; MARVEL; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..222
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 285 AA; 31509 MW; 7FF2C6E0B37235D4 CRC64;
MDSANQIVAT GTFQVLKVPL GFIRVLEWLF AIFAFATCGG YSGQLRVRVD CENKPDSNLS
INIDFAYPFR LNQVYVDVPT CKGRSQERLF LVGDFSSSAE FFVTIAVFAF LYSLLATVVY
IFFQNMYREN NRGPFIDFIV TVVFSFMWLV SSSAWAKGLS DVKVATDPEE VILLISACKV
QTNKCSSVYG PIWSGLNTSV VFGYLNFVLW AGNIWFVFKE TGWHKGGAAR YPTSAPEKQA
AAFNQQSYNQ GTFDQSGGGF SGSGDLGQTE YSQVGTYTSS GPTSY
//
